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MeSH Review

Psychomotor Disorders

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Disease relevance of Psychomotor Disorders


Psychiatry related information on Psychomotor Disorders


High impact information on Psychomotor Disorders


Chemical compound and disease context of Psychomotor Disorders


Biological context of Psychomotor Disorders

  • There was a trend towards psychomotor impairment (Concentration x time: p = 0.08), as measured by the Digit Symbol Substitution Test, with peak decrements in performance (about a minute after inhalation) being greater after 80% nitrous oxide than after 0% nitrous oxide [19].
  • A decrease in maternal circulating thyroxine during the first trimester, whether or not accompanied by increased circulating thyroid-stimulating hormone, may well result in irreversible mental and psychomotor impairments [20].
  • Because the D1 promoter, like other CNS-expressed promoters, confers transgene expression that is regionally restricted to different D1+ CNS subsets in different transgenic lines, we observed distinct but related psychomotor disorders in different D1CT-expressing founders [21].

Anatomical context of Psychomotor Disorders


Gene context of Psychomotor Disorders


Analytical, diagnostic and therapeutic context of Psychomotor Disorders


  1. Human dopamine D1 receptor encoded by an intronless gene on chromosome 5. Sunahara, R.K., Niznik, H.B., Weiner, D.M., Stormann, T.M., Brann, M.R., Kennedy, J.L., Gelernter, J.E., Rozmahel, R., Yang, Y.L., Israel, Y. Nature (1990) [Pubmed]
  2. Psychomotor adaptation in children with severe chronic asthma. Bender, B.G., Belleau, L., Fukuhara, J.T., Mrazek, D.A., Strunk, R.C. Pediatrics (1987) [Pubmed]
  3. The role of sertraline in the management of depression. Shelton, R.C. Clinical therapeutics. (1994) [Pubmed]
  4. The relevance of the in- versus outpatient status for studies on HPA-axis in depression: spontaneous hypercortisolism is a feature of major depressed inpatients and not of major depression per se. Maes, M., Calabrese, J., Meltzer, H.Y. Prog. Neuropsychopharmacol. Biol. Psychiatry (1994) [Pubmed]
  5. Psychomotor retardation, anorexia, weight loss, sleep disturbances, and loss of energy: psychopathological correlates of hyperhaptoglobinemia during major depression. Maes, M., Meltzer, H.Y., Scharpé, S., Cooreman, W., Uyttenbroeck, W., Suy, E., Vandervorst, C., Calabrese, J., Raus, J., Cosyns, P. Psychiatry research. (1993) [Pubmed]
  6. Dexmedetomidine premedication attenuates ketamine-induced cardiostimulatory effects and postanesthetic delirium. Levänen, J., Mäkelä, M.L., Scheinin, H. Anesthesiology (1995) [Pubmed]
  7. Development of acute tolerance after oral doses of diazepam and flunitrazepam. Ingum, J., Bjørklund, R., Volden, R., Mørland, J. Psychopharmacology (Berl.) (1994) [Pubmed]
  8. The psychopharmacological effects of premazepam, diazepam and placebo in healthy human subjects. Golombok, S., Lader, M. British journal of clinical pharmacology. (1984) [Pubmed]
  9. Troleandomycin-triazolam interaction in healthy volunteers: pharmacokinetic and psychometric evaluation. Warot, D., Bergougnan, L., Lamiable, D., Berlin, I., Bensimon, G., Danjou, P., Puech, A.J. Eur. J. Clin. Pharmacol. (1987) [Pubmed]
  10. Azapirones: an alternative to benzodiazepines for anxiety. Cadieux, R.J. American family physician. (1996) [Pubmed]
  11. Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis. Jayanthi, S., Deng, X., Ladenheim, B., McCoy, M.T., Cluster, A., Cai, N.S., Cadet, J.L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  12. Sedation and performance issues in the treatment of allergic conditions. Adelsberg, B.R. Arch. Intern. Med. (1997) [Pubmed]
  13. The P-300 event-related potential in experimental nitrous oxide exposure. Estrin, W.J., Moore, P., Letz, R., Wasch, H.H. Clin. Pharmacol. Ther. (1988) [Pubmed]
  14. Pharmacodynamic evaluation of the benzodiazepine-oral contraceptive interaction. Kroboth, P.D., Smith, R.B., Stoehr, G.P., Juhl, R.P. Clin. Pharmacol. Ther. (1985) [Pubmed]
  15. Effects of oral contraceptives on diazepam-induced psychomotor impairment. Ellinwood, E.H., Easler, M.E., Linnoila, M., Molter, D.W., Heatherly, D.G., Bjornsson, T.D. Clin. Pharmacol. Ther. (1984) [Pubmed]
  16. Diphenhydramine: kinetics and psychomotor effects in elderly women. Berlinger, W.G., Goldberg, M.J., Spector, R., Chiang, C.K., Ghoneim, M. Clin. Pharmacol. Ther. (1982) [Pubmed]
  17. Coadministration of nefazodone and benzodiazepines: I. Pharmacodynamic assessment. Kroboth, P.D., Folan, M.M., Lush, R.M., Chaikin, P.C., Shukla, U.A., Barbhaiya, R., Salazar, D.E. Journal of clinical psychopharmacology. (1995) [Pubmed]
  18. Flunitrazepam: a review of its pharmacological properties and therapeutic use. Mattila, M.A., Larni, H.M. Drugs (1980) [Pubmed]
  19. Time course of effects of brief inhalations of nitrous oxide in normal volunteers. Zacny, J.P., Lichtor, J.L., Coalson, D.W., Apfelbaum, J.L., Flemming, D., Foster, V. Addiction (1994) [Pubmed]
  20. The role of thyroid hormone in fetal neurodevelopment. Morreale de Escobar, G. Journal of pediatric endocrinology & metabolism : JPEM. (2001) [Pubmed]
  21. OCD-Like behaviors caused by a neuropotentiating transgene targeted to cortical and limbic D1+ neurons. Campbell, K.M., de Lecea, L., Severynse, D.M., Caron, M.G., McGrath, M.J., Sparber, S.B., Sun, L.Y., Burton, F.H. J. Neurosci. (1999) [Pubmed]
  22. Molecular pharmacology of second-generation antihistamines. Grant, J.A. Allergy and asthma proceedings : the official journal of regional and state allergy societies. (2000) [Pubmed]
  23. A case of complete adenylate kinase deficiency due to a nonsense mutation in AK-1 gene (Arg 107 --> Stop, CGA --> TGA) associated with chronic haemolytic anaemia. Bianchi, P., Zappa, M., Bredi, E., Vercellati, C., Pelissero, G., Barraco, F., Zanella, A. Br. J. Haematol. (1999) [Pubmed]
  24. Correlates and prevalence of benzodiazepine use in community-dwelling elderly. Gleason, P.P., Schulz, R., Smith, N.L., Newsom, J.T., Kroboth, P.D., Kroboth, F.J., Psaty, B.M. Journal of general internal medicine : official journal of the Society for Research and Education in Primary Care Internal Medicine. (1998) [Pubmed]
  25. The Assessment Unit of the Epilepsy Centre, Quarriers Homes. Gray, J.M., Espie, C. Scottish medical journal. (1991) [Pubmed]
  26. Cystic leukoencephalopathy without megalencephaly: a distinct disease entity in 15 children. Henneke, M., Preuss, N., Engelbrecht, V., Aksu, F., Bertini, E., Bibat, G., Brockmann, K., Hübner, C., Mayer, M., Mejaski-Bosnjak, V., Naidu, S., Neumaier-Probst, E., Rodriguez, D., Weisz, W., Kohlschütter, A., Gärtner, J. Neurology (2005) [Pubmed]
  27. Flumazenil reversal of psychomotor impairment due to midazolam or diazepam for conscious sedation for upper endoscopy. Kankaria, A., Lewis, J.H., Ginsberg, G., Gallagher, J., al-Kawas, F.H., Nguyen, C.C., Fleischer, D.E., Benjamin, S.B. Gastrointest. Endosc. (1996) [Pubmed]
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