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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Increased susceptibility to cephamycin-type antibiotics of methicillin-resistant Staphylococcus aureus defective in penicillin-binding protein 2.

A methicillin-resistant strain of Staphylococcus aureus which produced low-affinity penicillin-binding protein 2' (PBP 2') spontaneously lost PBP 2 when the strain was cultivated at 43 degrees C overnight. At 37 degrees C, the mutant had increased susceptibility to cephamycin-type beta-lactams, which showed high affinity for PBP 4. This result suggests that inhibition of PBP 4, in addition to that of PBP 2, is necessary to kill methicillin-resistant strains.[1]


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