Lack of effect of thymus and spleen on the incubation period of Creutzfeldt-Jakob disease in mice.
Genetically athymic and asplenic (Lasat), athymic ( Nude), asplenic (Dh) or normal littermate (Hetero) mice with a BALB/c genetic background were injected either intracerebrally or intraperitoneally with a 1% or 10% homogenate of mouse brains infected with the Fukuoka 1 strain of the Creutzfeldt-Jakob disease (CJD) agent. As there were no significant differences in incubation periods among the five groups (Lasat, Nude, Dh, Hetero and BALB/c) inoculated with the same dilution, via the same route, it was concluded that cell-mediated immunity dependent on the thymus plays no significant role in host defence against the CJD agent, and the spleen, a critical site of agent replication, is apparently not an obligatory source from which infection spreads to the central nervous system.[1]References
- Lack of effect of thymus and spleen on the incubation period of Creutzfeldt-Jakob disease in mice. Mohri, S., Handa, S., Tateishi, J. J. Gen. Virol. (1987) [Pubmed]
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