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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Methylphenidate affects strategic choice behavior in normal adult humans.

The time course of serum concentration and performance on a concurrent probability matching task were evaluated in normal adults receiving 0.15 or 0.3 mg/kg of methylphenidate. The behavioral task, an arcade-like problem-solving game, revealed that drug-treated subjects improved their performance upon repeated testings during pharmacokinetic evaluation at a lower rate than did non-treated controls over the same time span. However, drug-treated subjects failed to adopt the adaptive problem-solving strategies selected by controls.[1]


  1. Methylphenidate affects strategic choice behavior in normal adult humans. Schroeder, S.R., Mann-Koepke, K., Gualtieri, C.T., Eckerman, D.A., Breese, G.R. Pharmacol. Biochem. Behav. (1987) [Pubmed]
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