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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Alloviroidin, the naturally occurring toxic isomer of the cyclopeptide viroidin.

A novel toxic cyclopeptide from Amanita suballiacea (Murr.) mushrooms that possesses structural features similar to viroidin is described. This peptide, alloviroidin, is identical with viroidin in mass, affinity for actin, and all amino acids except for one. The single discernible difference between the two peptides exists in the configuration at carbon 4 of the 4,5-dihydroxyleucine residues, as shown by a combination of chemical modification and magnetic resonance experiments. The configuration of this residue in viroidin is similar to that of phalloidin and is 2S,4R, while that in alloviroidin is established to be 2S,4S. This peptide is thus unique in its hydroxylation pattern among both the virotoxins and phallotoxins and may be an intermediate for more highly hydroxylated virotoxins, such as viroisin.[1]

References

  1. Alloviroidin, the naturally occurring toxic isomer of the cyclopeptide viroidin. Little, M.C., Preston, J.F., Jackson, C., Bonetti, S., King, R.W., Taylor, L.C. Biochemistry (1986) [Pubmed]
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