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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Urine discoloration after acetaminophen overdose.

Three patients with acetaminophen overdose were observed to have dark-brown urine at an early stage of their illness. Subsequently, acute anuric renal failure and hepatic dysfunction developed in all three. p-Aminophenol was identified by chromatographic and colorimetric methods in the urine of each case and is thought to be responsible for the discoloration.[1]


  1. Urine discoloration after acetaminophen overdose. Clark, P.M., Clark, J.D., Wheatley, T. Clin. Chem. (1986) [Pubmed]
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