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Chemical Compound Review

Azol     4-aminophenol

Synonyms: Certinal, Energol, Paranol, Rodinal, Citol, ...
 
 
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Disease relevance of Azol

 

High impact information on Azol

 

Chemical compound and disease context of Azol

 

Biological context of Azol

 

Anatomical context of Azol

 

Associations of Azol with other chemical compounds

 

Gene context of Azol

  • A secondary DNA probe labeled with alkaline phosphatase (AP) was then hybridized to base sequence 1039-1062 on the target. p-Aminophenol, which is enzymatically generated by the immobilized AP from p-aminophenyl phosphate (PAPP), is detected using electrochemistry [29].
  • Heterogeneous enzyme immunoassay of alpha-fetoprotein in maternal serum by flow-injection amperometric detection of 4-aminophenol [30].
  • The enzyme label beta-GAL converted the substrate 4-aminophenyl-beta-D-galactopyranoside (4-APG) into 4-aminophenol (4-AP), which subsequently was detected by a cellobiose dehydrogenase (CDH) modified solid graphite electrode [31].
  • Electrochemical Immunosensor Using p-Aminophenol Redox Cycling by Hydrazine Combined with a Low Background Current [25].
  • In contrast to the reduction in CDDP, Hg2+ and Cd2+ toxicity, the reduction in p-aminophenol toxicity cannot be explained by the metal-binding properties of MT [4].
 

Analytical, diagnostic and therapeutic context of Azol

  • Small-volume voltammetric detection of 4-aminophenol with interdigitated array electrodes and its application to electrochemical enzyme immunoassay [32].
  • A small-volume voltammetric detection of 4-aminophenol (PAP) has been developed using an interdigitated array (IDA) microelectrode cell in order to apply the IDA to electrochemical enzyme immunoassay [32].
  • The immunoassay sandwich was made by attaching a biotinylated rabbit anti-MS2 IgG to a streptavidin-coated bead, capturing the virus, and then attaching a rabbit anti-MS2 IgG-beta-galactosidase conjugate to another site on the virus. beta-Galactosidase converts p-aminophenyl galactopyranoside (PAPG) to p-aminophenol (PAP) [33].
  • No free p-aminophenol could be detected in the perfusion medium and only a small amount in the bile [34].
  • The bioelectrocatalytic properties of this biosensor offer an additional amplification and thus allow a very sensitive quantification of 4-aminophenol, generated by the beta-galactosidase [35].

References

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  25. Electrochemical Immunosensor Using p-Aminophenol Redox Cycling by Hydrazine Combined with a Low Background Current. Das, J., Jo, K., Lee, J.W., Yang, H. Anal. Chem. (2007) [Pubmed]
  26. Competitive heterogeneous enzyme immunoassay for theophylline by flow-injection analysis with electrochemical detection of p-aminophenol. Gil, E.P., Tang, H.T., Halsall, H.B., Heineman, W.R., Misiego, A.S. Clin. Chem. (1990) [Pubmed]
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  30. Heterogeneous enzyme immunoassay of alpha-fetoprotein in maternal serum by flow-injection amperometric detection of 4-aminophenol. Xu, Y., Halsall, B., Heineman, W.R. Clin. Chem. (1990) [Pubmed]
  31. An enzyme flow immunoassay that uses beta-galactosidase as the label and a cellobiose dehydrogenase biosensor as the label detector. Burestedt, E., Nistor, C., Schagerlöf, U., Emnéus, J. Anal. Chem. (2000) [Pubmed]
  32. Small-volume voltammetric detection of 4-aminophenol with interdigitated array electrodes and its application to electrochemical enzyme immunoassay. Niwa, O., Xu, Y., Halsall, H.B., Heineman, W.R. Anal. Chem. (1993) [Pubmed]
  33. Bead-based electrochemical immunoassay for bacteriophage MS2. Thomas, J.H., Kim, S.K., Hesketh, P.J., Halsall, H.B., Heineman, W.R. Anal. Chem. (2004) [Pubmed]
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