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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Penicillin levels in blood and CSF achieved by treatment of syphilis.

Treponemicidal levels of penicillin in the CSF were not obtained following intramuscular (IM) injections of 600,000 IU of penicillin G procaine along with 2% aluminum monostearate ( PAM). Treponemicidal levels of penicillin in the CSF were achieved in 31 patients by probenecid, 500 mg/6 hr by mouth, with penicillin G, 500,000 IU by IM injection, and by probenecid every six hours by mouth and IM injections of penicillin G procaine once a day in two of three patients following injections of 600,000 IU, in four of five following 1.2 million IU, and in three (now all nine) following 2.4 million IU.[1]

References

  1. Penicillin levels in blood and CSF achieved by treatment of syphilis. Dunlop, E.M., Al-Egaily, S.S., Houang, E.T. JAMA (1979) [Pubmed]
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