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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Syphilis


Psychiatry related information on Syphilis

  • Alternatively, we reasoned that if anti-Fn autoantibodies played a role in the pathogenesis of syphilis, then down-regulation of such a response by the Id network might directly affect progression of the disease [6].

High impact information on Syphilis


Chemical compound and disease context of Syphilis


Biological context of Syphilis


Anatomical context of Syphilis


Gene context of Syphilis

  • In contrast to a lesion from a patient with recurrent herpes simplex virus type 2, no message for IL-4 could be detected in any of the syphilis lesions, and 10 of 13 had no mRNA for IL-5 or IL-13 [25].
  • VEGF intensity appeared increased in the patients with secondary syphilis [26].
  • In this stage of syphilis again slightly increased the ability of cells to secrete IL-10, which reached the highest value in early latent syphilis [27].
  • The whole process may play an important role in the immunopathogenesis of syphilis and it is likely that TNF-alpha and IL-1alpha are involved [28].
  • In syphilis, reactivity with macrophage markers such as lysozyme and MAC387 were weaker, and reactivity to HLA-DR and S-100 was much stronger [29].

Analytical, diagnostic and therapeutic context of Syphilis


  1. The response of symptomatic neurosyphilis to high-dose intravenous penicillin G in patients with human immunodeficiency virus infection. Gordon, S.M., Eaton, M.E., George, R., Larsen, S., Lukehart, S.A., Kuypers, J., Marra, C.M., Thompson, S. N. Engl. J. Med. (1994) [Pubmed]
  2. Alteration in the natural history of neurosyphilis by concurrent infection with the human immunodeficiency virus. Johns, D.R., Tierney, M., Felsenstein, D. N. Engl. J. Med. (1987) [Pubmed]
  3. Treponemal infection in a Pleistocene bear. Rothschild, B.M., Turnbull, W. Nature (1987) [Pubmed]
  4. Fibronectin tetrapeptide is target for syphilis spirochete cytadherence. Thomas, D.D., Baseman, J.B., Alderete, J.F. J. Exp. Med. (1985) [Pubmed]
  5. Antiphospholipid antibodies--autoantibodies with a difference. Harris, E.N., Asherson, R.A., Hughes, G.R. Annu. Rev. Med. (1988) [Pubmed]
  6. Evidence that autologous idiotypic regulation of anti-arginine-glycine-aspartic acid autoantibodies may influence development and progression of syphilitic lesions in infected rabbits. Baughn, R.E., Musher, D.M. Infect. Immun. (1992) [Pubmed]
  7. A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. The Syphilis and HIV Study Group. Rolfs, R.T., Joesoef, M.R., Hendershot, E.F., Rompalo, A.M., Augenbraun, M.H., Chiu, M., Bolan, G., Johnson, S.C., French, P., Steen, E., Radolf, J.D., Larsen, S. N. Engl. J. Med. (1997) [Pubmed]
  8. Congenital syphilis presenting in infants after the newborn period. Dorfman, D.H., Glaser, J.H. N. Engl. J. Med. (1990) [Pubmed]
  9. Landmark perspective: Penicillin and early syphilis. Arnold, H.L. JAMA (1984) [Pubmed]
  10. Lupus anticoagulant activity of autoimmune antiphospholipid antibodies is dependent upon beta 2-glycoprotein I. Roubey, R.A., Pratt, C.W., Buyon, J.P., Winfield, J.B. J. Clin. Invest. (1992) [Pubmed]
  11. Targeted mass treatment for syphilis with oral azithromycin. Rekart, M.L., Patrick, D.M., Chakraborty, B., Maginley, J.J., Jones, H.D., Bajdik, C.D., Pourbohloul, B., Brunham, R.C. Lancet (2003) [Pubmed]
  12. Amoxycillin, syphilis, and HIV infection. Hay, P.E., Taylor-Robinson, D., Waldron, S., Goldmeier, D. Lancet (1990) [Pubmed]
  13. Rational drug design: a multidisciplinary approach. Hunter, W.N. Molecular medicine today. (1995) [Pubmed]
  14. Humoral response in Treponema pallidum-infected guinea pigs. II. Circulating immune complexes and autoimmune responses. Baughn, R.E., Wicher, V., Jakubowski, A., Wicher, K. J. Immunol. (1987) [Pubmed]
  15. Transmission of human herpesvirus 8 by sexual activity among adults in Lagos, Nigeria. Eltom, M.A., Mbulaiteye, S.M., Dada, A.J., Whitby, D., Biggar, R.J. AIDS (2002) [Pubmed]
  16. A randomized, double-blind, placebo-controlled trial of single-dose ciprofloxacin versus erythromycin for the treatment of chancroid in Nairobi, Kenya. Malonza, I.M., Tyndall, M.W., Ndinya-Achola, J.O., Maclean, I., Omar, S., MacDonald, K.S., Perriens, J., Orle, K., Plummer, F.A., Ronald, A.R., Moses, S. J. Infect. Dis. (1999) [Pubmed]
  17. Public health intervention in a cocaine-related syphilis outbreak. Hibbs, J.R., Gunn, R.A. American journal of public health. (1991) [Pubmed]
  18. Heated versus unheated sera in the hemagglutination treponemal test for syphilis. Hambie, E.A., Larsen, S.A., Perryman, M.W., Pettit, D.E., Feeley, J.C. J. Clin. Microbiol. (1982) [Pubmed]
  19. Risk factors for syphilis: cocaine use and prostitution. Rolfs, R.T., Goldberg, M., Sharrar, R.G. American journal of public health. (1990) [Pubmed]
  20. Autoantibodies to phospholipids and to the coagulation proteins in AIDS. Abuaf, N., Laperche, S., Rajoely, B., Carsique, R., Deschamps, A., Rouquette, A.M., Barthet, C., Khaled, Z., Marbot, C., Saab, N., Rozen, J., Girard, P.M., Rozenbaum, W. Thromb. Haemost. (1997) [Pubmed]
  21. "Tree-barking" of the ascending aorta. Syphilis or systemic lupus erythematosus? MacLeod, C.B., Johnson, D., Frable, W.J. Am. J. Clin. Pathol. (1992) [Pubmed]
  22. Comparison of maternal sera, cord blood, and neonatal sera for detecting presumptive congenital syphilis: relationship with maternal treatment. Chhabra, R.S., Brion, L.P., Castro, M., Freundlich, L., Glaser, J.H. Pediatrics (1993) [Pubmed]
  23. Prenatal care in cocaine-exposed pregnancies. Burkett, G., Gomez-Marin, O., Yasin, S.Y., Martinez, M. Obstetrics and gynecology. (1998) [Pubmed]
  24. Clinical significance of low molecular weight IgM in patients with systemic lupus erythematosus. Harisdangkul, V., Barnes, T.Y., Songcharoen, S., Pennebaker, J.B. J. Rheumatol. (1984) [Pubmed]
  25. Primary and secondary syphilis lesions contain mRNA for Th1 cytokines. Van Voorhis, W.C., Barrett, L.K., Koelle, D.M., Nasio, J.M., Plummer, F.A., Lukehart, S.A. J. Infect. Dis. (1996) [Pubmed]
  26. Cutaneous lesions of secondary syphilis are highly angiogenic. Macaron, N.C., Cohen, C., Chen, S.C., Arbiser, J.L. J. Am. Acad. Dermatol. (2003) [Pubmed]
  27. The pattern and level of cytokines secreted by Th1 and Th2 lymphocytes of syphilitic patients correlate to the progression of the disease. Podwinska, J., Lusiak, M., Zaba, R., Bowszyc, J. FEMS Immunol. Med. Microbiol. (2000) [Pubmed]
  28. Virulent Treponema pallidum 47 kDa antigen regulates the expression of cell adhesion molecules and binding of T-lymphocytes to cultured human dermal microvascular endothelial cells. Lee, K.H., Choi, H.J., Lee, M.G., Lee, J.B. Yonsei Med. J. (2000) [Pubmed]
  29. Phenotype of villous stromal cells in placentas with cytomegalovirus, syphilis, and nonspecific villitis. Greco, M.A., Wieczorek, R., Sachdev, R., Kaplan, C., Nuovo, G.J., Demopoulos, R.I. Am. J. Pathol. (1992) [Pubmed]
  30. Two different subtypes of antimitochondrial antibodies are associated with primary biliary cirrhosis: identification and characterization by radioimmunoassay and immunoblotting. Manns, M., Gerken, G., Kyriatsoulis, A., Trautwein, C., Reske, K., Meyer Zum Büschenfelde, K.H. Hepatology (1987) [Pubmed]
  31. Is anticardiolipin activity a cross-reaction of anti-DNA or a separate entity? Smeenk, R.J., Lucassen, W.A., Swaak, T.J. Arthritis Rheum. (1987) [Pubmed]
  32. Use of an enzyme-linked immunosorbent assay and of inhibition studies to distinguish between antibodies to cardiolipin from patients with syphilis or autoimmune disorders. Harris, E.N., Gharavi, A.E., Wasley, G.D., Hughes, G.R. J. Infect. Dis. (1988) [Pubmed]
  33. Molecular subtyping of Treponema pallidum in an Arizona County with increasing syphilis morbidity: use of specimens from ulcers and blood. Sutton, M.Y., Liu, H., Steiner, B., Pillay, A., Mickey, T., Finelli, L., Morse, S., Markowitz, L.E., St Louis, M.E. J. Infect. Dis. (2001) [Pubmed]
  34. Syphilis in pregnancy in Tanzania. II. The effectiveness of antenatal syphilis screening and single-dose benzathine penicillin treatment for the prevention of adverse pregnancy outcomes. Watson-Jones, D., Gumodoka, B., Weiss, H., Changalucha, J., Todd, J., Mugeye, K., Buvé, A., Kanga, Z., Ndeki, L., Rusizoka, M., Ross, D., Marealle, J., Balira, R., Mabey, D., Hayes, R. J. Infect. Dis. (2002) [Pubmed]
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