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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Effects of melatonin, serotonin, and naloxone on aggression in isolated cichlid fish (Aequidens pulcher).

Intracranial injections of 10 micrograms melatonin, with or without 4 micrograms naloxone, result in reduced aggressive responsiveness by the cichlid fish Aequidens pulcher to a mirror presented 20 min later. Naloxone, when administered on its own, had no behavioral effect. Intracranial injections of 25 micrograms serotonin-creatinine sulphate complex (5HT-CS) also reduced aggression. 5HT-CS's action was abolished if the injection included 10 micrograms S-adenosyl homocysteine ( SAH), which inhibits the conversion of serotonin to melatonin. This suggests that the behavioral action of 5HT-CS may be mediated by its conversion to melatonin. There is inconclusive evidence to suggest that 37.5 micrograms 5HT-CS, administered in conjunction with 10 micrograms SAH, may reduce aggressiveness; injection of 50 micrograms 5HT-CS, with or without 10 micrograms SAH, induced a pronounced escape behavior which precluded any measurement of aggressiveness in the fish.[1]

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