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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A novel human gene closely related to the abl proto-oncogene.

A DNA sequence related to the abl proto-oncogene was identified in human placenta. Molecular cloning and nucleotide sequence analysis revealed two putative exons whose predicted amino acid sequence was most homologous to the corresponding sequences of c-abl and v-abl but was related to other tyrosine kinase genes as well. The new sequence was localized by in situ hybridization and somatic cell genetic analysis to human chromosome 1q24-25, which differs from the location of any previously identified tyrosine kinase gene. The detection of a novel 12-kb transcript by this gene in human normal and tumor cells establishes it as a new member of the tyrosine kinase family that is closely related to but distinct from c-abl.[1]


  1. A novel human gene closely related to the abl proto-oncogene. Kruh, G.D., King, C.R., Kraus, M.H., Popescu, N.C., Amsbaugh, S.C., McBride, W.O., Aaronson, S.A. Science (1986) [Pubmed]
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