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Lotzová, E. et al.

Pyrimidinones: inducers of NK cell activity and antitumor immunity.

We have shown that pyrimidinone molecule, 2 amino-5-iodo-6-phenyl-4-pyrimidinone ( AIPP) after regional administration, displayed both prophylactic and therapeutic effect on ascitic mammary adenocarcinoma, ACA-755. The antitumor effect was mediated by natural killer (NK) cells, since depletion of this lymphocyte population resulted in abrogation of AIPP-induced tumor resistance. This observation confirms the role of NK cells in antitumor immunity and suggests that AIPP may be therapeutically beneficial also in man.[1]

References

Pyrimidinones: inducers of NK cell activity and antitumor immunity. Lotzová, E., Savary, C.A. Comp. Immunol. Microbiol. Infect. Dis. (1986) [Pubmed]

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