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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Catabolism of pentachlorophenol by a Flavobacterium sp.

The pathway employed for pentachlorophenol (PCP) degradation by an aerobic, chlorophenol-utilizing Flavobacterium sp. was initiated by conversion of PCP to tetrachloro-p-hydroquinone (TCH). 18O labelling experiments demonstrated that the first dechlorination, where a hydroxyl replaced the chlorine at PCP ring position number 4, involved a hydrolytic reaction. Then two reductive dechlorinations of TCH followed to yield firstly trichlorohydroquinone (TrCH) and then 2,6-dichlorohydroquinone (DCH). Thus, the initial steps in catabolism of PCP by the Flavobacterium were: PCP----TCH----TrCH.[1]


  1. Catabolism of pentachlorophenol by a Flavobacterium sp. Steiert, J.G., Crawford, R.L. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
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