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Hromas, R.A. et al.

Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells.

Little is understood about the mechanism of acquired resistance to the widely used antineoplastic drug, cisplatin. The cisplatin-resistant murine leukemia L1210 cell line L1210/ PAM has an elevated cellular glutathione content, as compared to its sensitive parent cell line, L1210/*. Exposure to D,L-buthionine-S,R-sulfoximine reduced L1210/ PAM cells' glutathione content to nearly that of L1210/* cells and abrogated the resistance to cisplatin.[1]

References

Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells. Hromas, R.A., Andrews, P.A., Murphy, M.P., Burns, C.P. Cancer Lett. (1987) [Pubmed]

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