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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells.

Little is understood about the mechanism of acquired resistance to the widely used antineoplastic drug, cisplatin. The cisplatin-resistant murine leukemia L1210 cell line L1210/ PAM has an elevated cellular glutathione content, as compared to its sensitive parent cell line, L1210/*. Exposure to D,L-buthionine-S,R-sulfoximine reduced L1210/ PAM cells' glutathione content to nearly that of L1210/* cells and abrogated the resistance to cisplatin.[1]

References

  1. Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells. Hromas, R.A., Andrews, P.A., Murphy, M.P., Burns, C.P. Cancer Lett. (1987) [Pubmed]
 
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