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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

The growth and histological characteristics of a series of human bladder cancer xenografts.

Xenografts from human transitional cell carcinoma of the bladder ( TCC) have been successfully established in CBA mice which had previously been immune-deprived by thymectomy and whole body irradiation with cytosine arabinoside pre-treatment. Xenografts were established from 3/17 patients with histological grade 2 tumours, 3/19 patients with histological grade 3 tumours, and one from a patient with a mixed transitional cell and squamous cell carcinoma. No xenografts were established from patients with histological grade 1 tumours. All the xenografts maintained the histological characteristics of their parent tumours in early passage, but some developed more prominent squamous features in later generations. Many of the xenografts were cystic.[1]

References

  1. The growth and histological characteristics of a series of human bladder cancer xenografts. Hay, J.H., Busuttil, A., Steel, C.M., Duncan, W. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology. (1986) [Pubmed]
 
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