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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Is there a serotonergic tonic descending inhibition on the responses of dorsal horn convergent neurons to C-fibre inputs?

In the anaesthetized rat the intravenous injection of 5-HT antagonists, cinanserin and methysergide, induces in two-thirds of neurones studied, an increase in the responsiveness of dorsal horn convergent neurones to C-fibre stimulation. These results are in favour of the existence of serotonergic tonic descending inhibitory effects on the spinal transmission of noxious messages.[1]

References

  1. Is there a serotonergic tonic descending inhibition on the responses of dorsal horn convergent neurons to C-fibre inputs? Rivot, J.P., Calvino, B., Besson, J.M. Brain Res. (1987) [Pubmed]
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