Cloning and chromosomal location of the alpha- and beta-globin genes from a marsupial.
The cDNA sequences encoding the adult alpha- and beta-globin polypeptides of a marsupial, the native cat Dasyurus viverrinus, have been cloned and their nucleotide sequences have been determined. Using these cDNA clones we have determined the chromosomal location of the native cat alpha- and beta-globin genes by in situ hybridization to fixed metaphase chromosomes and by hybridization to DNA extracted from chromosomes purified by a fluorescence-activated cell sorter. Using two independent methods of gene assignment we have shown the alpha- and beta-globin-like gene sequences to be asyntenic in the native cat, the alpha-globin-like sequences being on chromosome 2 and the beta-globin-like sequences being on chromosome 4.[1]References
- Cloning and chromosomal location of the alpha- and beta-globin genes from a marsupial. Wainwright, B., Hope, R. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
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