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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Aspartame use by persons with diabetes.

Sixty-two subjects having either insulin-dependent or non-insulin-dependent diabetes completed a randomized, double-blind study comparing effects of aspartame or a placebo on blood glucose control. Twenty-nine subjects consumed 2.7 g aspartame per day for 18 wk, given as aspartame-containing capsules with meals, while 33 subjects took identical appearing placebo capsules. After 18 wk, no changes were seen in fasting or 2-h postprandial blood glucose levels or glycohemoglobin levels in either the aspartame- or placebo-treated groups. Adverse reactions were no more common in the group taking aspartame. We conclude that use of aspartame as a low-calorie sweetener does not adversely affect glycemic control of persons with diabetes.[1]


  1. Aspartame use by persons with diabetes. Nehrling, J.K., Kobe, P., McLane, M.P., Olson, R.E., Kamath, S., Horwitz, D.L. Diabetes Care (1985) [Pubmed]
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