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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions.

Leu-2/T8 is a cell surface glycoprotein expressed by most cytotoxic and suppressor T lymphocytes. Its expression on T cells correlates best with recognition of class I major histocompatibility complex antigens, and it has been postulated to be a receptor for these proteins. We have determined the complete primary structure of Leu-2/T8 from the nucleotide sequence of its cDNA. The protein contains a classical signal peptide, two external domains, a hydrophobic transmembrane region, and a cytoplasmic tail. The N-terminal domain of the protein has striking homology to variable regions of immunoglobulins and the T cell receptor. The membrane-proximal domain appears to be a hinge-like region similar to that of immunoglobulin heavy chains. The superfamily of immunologically important surface molecules can now be extended to include Leu-2/T8.[1]

References

  1. The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions. Sukhatme, V.P., Sizer, K.C., Vollmer, A.C., Hunkapiller, T., Parnes, J.R. Cell (1985) [Pubmed]
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