Gene Review:
CD8A - CD8a molecule
Homo sapiens
Synonyms:
CD8, Leu2, MAL, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, ...
Zimmer,
Naim,
Weber,
Ellis,
Ciclitira,
Marschall,
Marzi,
aus dem Siepen,
Jochmann,
Kalmer,
Auerochs,
Lischka,
Leis,
Stamminger,
Kovacs,
Lempicki,
Sidorov,
Adelsberger,
Herpin,
Metcalf,
Sereti,
Polis,
Davey,
Tavel,
Falloon,
Stevens,
Lambert,
Dewar,
Schwartzentruber,
Anver,
Baseler,
Masur,
Dimitrov,
Lane,
Kioussis,
Ellmeier,
de la Calle-Martin,
Hernandez,
Ordi,
Casamitjana,
Arostegui,
Caragol,
Ferrando,
Labrador,
Rodriguez-Sanchez,
Espanol,
- Familial CD8 deficiency due to a mutation in the CD8 alpha gene. de la Calle-Martin, O., Hernandez, M., Ordi, J., Casamitjana, N., Arostegui, J.I., Caragol, I., Ferrando, M., Labrador, M., Rodriguez-Sanchez, J.L., Espanol, T. J. Clin. Invest. (2001)
- Prognostic factors in childhood T-cell acute lymphoblastic leukemia: a Pediatric Oncology Group study. Shuster, J.J., Falletta, J.M., Pullen, D.J., Crist, W.M., Humphrey, G.B., Dowell, B.L., Wharam, M.D., Borowitz, M. Blood (1990)
- Cellular p32 recruits cytomegalovirus kinase pUL97 to redistribute the nuclear lamina. Marschall, M., Marzi, A., aus dem Siepen, P., Jochmann, R., Kalmer, M., Auerochs, S., Lischka, P., Leis, M., Stamminger, T. J. Biol. Chem. (2005)
- Double-negative (CD4- CD8-) T cells with an alpha/beta T cell receptor. Non-MHC-restricted cytolytic activity and lymphokine production. Brooks, E.G., Wirt, D.P., Goldblum, R.M., Vaidya, S., Asuncion, M.T., Patterson, J.C., Ware, C.F., Klimpel, G.R. J. Immunol. (1990)
- T cells of atopic asthmatics preferentially infiltrate into human bronchial xenografts in SCID mice. Tsumori, K., Kohrogi, H., Goto, E., Hirata, N., Hirosako, S., Fujii, K., Ando, M., Kawano, O., Mizuta, H. J. Immunol. (2003)
- Patterns of CD8 T cell clonal dominance in response to change in antiretroviral therapy in HIV-infected children. Kharbanda, M., Than, S., Chitnis, V., Sun, M., Chavan, S., Bakshi, S., Pahwa, S. AIDS (2000)
- Risk factors associated with Epstein-Barr virus replication in oral epithelial cells of HIV-infected individuals. Boulter, A.W., Soltanpoor, N., Swan, A.V., Birnbaum, W., Johnson, N.W., Teo, C.G. AIDS (1996)
- Immunological changes in young and old adults during brief laboratory stress. Naliboff, B.D., Benton, D., Solomon, G.F., Morley, J.E., Fahey, J.L., Bloom, E.T., Makinodan, T., Gilmore, S.L. Psychosomatic medicine. (1991)
- Prospective associations between lateralised brain function and immune status in HIV infection: analysis of EEG, cognition and mood over 30 months. Gruzelier, J., Burgess, A., Baldeweg, T., Riccio, M., Hawkins, D., Stygall, J., Catt, S., Irving, G., Catalan, J. International journal of psychophysiology : official journal of the International Organization of Psychophysiology. (1996)
- Nutritional status and immunocompetence in eating disorders. A comparative study. Marcos, A., Varela, P., Santacruz, I., Muñoz-Vélez, A., Morandé, G. European journal of clinical nutrition. (1993)
- How do monoclonal antibodies induce tolerance? A role for infectious tolerance? Waldmann, H., Cobbold, S. Annu. Rev. Immunol. (1998)
- Regulation of lymphocyte function by protein phosphorylation. Perlmutter, R.M., Levin, S.D., Appleby, M.W., Anderson, S.J., Alberola-Ila, J. Annu. Rev. Immunol. (1993)
- Actin dynamics control SRF activity by regulation of its coactivator MAL. Miralles, F., Posern, G., Zaromytidou, A.I., Treisman, R. Cell (2003)
- Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution. Leahy, D.J., Axel, R., Hendrickson, W.A. Cell (1992)
- Identification of dynamically distinct subpopulations of T lymphocytes that are differentially affected by HIV. Kovacs, J.A., Lempicki, R.A., Sidorov, I.A., Adelsberger, J.W., Herpin, B., Metcalf, J.A., Sereti, I., Polis, M.A., Davey, R.T., Tavel, J., Falloon, J., Stevens, R., Lambert, L., Dewar, R., Schwartzentruber, D.J., Anver, M.R., Baseler, M.W., Masur, H., Dimitrov, D.S., Lane, H.C. J. Exp. Med. (2001)
- Cytotoxicity of sulfonamide reactive metabolites: apoptosis and selective toxicity of CD8(+) cells by the hydroxylamine of sulfamethoxazole. Hess, D.A., Sisson, M.E., Suria, H., Wijsman, J., Puvanesasingham, R., Madrenas, J., Rieder, M.J. FASEB J. (1999)
- Human immunodeficiency virus type 2 envelope glycoprotein binds to CD8 as well as to CD4 molecules on human T cells. Kaneko, H., Neoh, L.P., Takeda, N., Akimoto, H., Hishikawa, T., Hashimoto, H., Hirose, S., Karaki, S., Takiguchi, M., Nakauchi, H., Kaneko, Y., Yamamoto, N., Sekigawa, I. J. Virol. (1997)
- Spectrum of CD4 to CD8 T-cell ratios in lymphocytic alveolitis associated with methotrexate-induced pneumonitis. Fuhrman, C., Parrot, A., Wislez, M., Prigent, H., Boussaud, V., Bernaudin, J.F., Mayaud, C., Cadranel, J. Am. J. Respir. Crit. Care Med. (2001)
- Chronic hypersensitivity pneumonitis in Japan: a nationwide epidemiologic survey. Yoshizawa, Y., Ohtani, Y., Hayakawa, H., Sato, A., Suga, M., Ando, M. J. Allergy Clin. Immunol. (1999)
- Linkage of the murine transforming growth factor alpha gene with Igk, Ly-2, and Fabp1 on chromosome 6. Fowler, K.J., Mann, G.B., Dunn, A.R. Genomics (1993)
- Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation. Kioussis, D., Ellmeier, W. Nat. Rev. Immunol. (2002)
- The T cell differentiation antigen Leu-2/T8 is homologous to immunoglobulin and T cell receptor variable regions. Sukhatme, V.P., Sizer, K.C., Vollmer, A.C., Hunkapiller, T., Parnes, J.R. Cell (1985)
- Isolation of CD4- CD8- mycobacteria-reactive T lymphocyte clones from rheumatoid arthritis synovial fluid. Holoshitz, J., Koning, F., Coligan, J.E., De Bruyn, J., Strober, S. Nature (1989)
- Variable-constant segment genotype of immunoglobulin kappa is associated with increased risk for rheumatoid arthritis. Moxley, G. Arthritis Rheum. (1992)
- Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2. Gao, G.F., Tormo, J., Gerth, U.C., Wyer, J.R., McMichael, A.J., Stuart, D.I., Bell, J.I., Jones, E.Y., Jakobsen, B.K. Nature (1997)
- Cell-cell adhesion mediated by CD8 and human histocompatibility leukocyte antigen G, a nonclassical major histocompatibility complex class 1 molecule on cytotrophoblasts. Sanders, S.K., Giblin, P.A., Kavathas, P. J. Exp. Med. (1991)
- Evidence for differential intracellular signaling via CD4 and CD8 molecules. Ravichandran, K.S., Burakoff, S.J. J. Exp. Med. (1994)
- Human CD8 beta, but not mouse CD8 beta, can be expressed in the absence of CD8 alpha as a beta beta homodimer. Devine, L., Kieffer, L.J., Aitken, V., Kavathas, P.B. J. Immunol. (2000)
- Four Functionally Distinct Populations of Human Effector-Memory CD8+ T Lymphocytes. Romero, P., Zippelius, A., Kurth, I., Pittet, M.J., Touvrey, C., Iancu, E.M., Corthesy, P., Devevre, E., Speiser, D.E., Rufer, N. J. Immunol. (2007)
- Differential regulation of Ca2+ mobilization in human thymocytes by coaggregation of surface molecules. Deusch, K., Daley, J.F., Levine, H., Languet, A.J., Anderson, P., Schlossman, S.F., Blue, M.L. J. Immunol. (1990)
- Human CD4-major histocompatibility complex class II (DQw6) transgenic mice in an endogenous CD4/CD8-deficient background: reconstitution of phenotype and human-restricted function. Yeung, R.S., Penninger, J.M., Kündig, T.M., Law, Y., Yamamoto, K., Kamikawaji, N., Burkly, L., Sasazuki, T., Flavell, R., Ohashi, P.S., Mak, T.W. J. Exp. Med. (1994)
- Identification of a candidate regulatory region in the human CD8 gene complex by colocalization of DNase I hypersensitive sites and matrix attachment regions which bind SATB1 and GATA-3. Kieffer, L.J., Greally, J.M., Landres, I., Nag, S., Nakajima, Y., Kohwi-Shigematsu, T., Kavathas, P.B. J. Immunol. (2002)
- Polymorphism in the alpha 3 domain of HLA-A molecules affects binding to CD8. Salter, R.D., Norment, A.M., Chen, B.P., Clayberger, C., Krensky, A.M., Littman, D.R., Parham, P. Nature (1989)
- Soluble HLA-A,-B,-C and -G molecules induce apoptosis in T and NK CD8+ cells and inhibit cytotoxic T cell activity through CD8 ligation. Contini, P., Ghio, M., Poggi, A., Filaci, G., Indiveri, F., Ferrone, S., Puppo, F. Eur. J. Immunol. (2003)
- Increase of peripheral CXCR3 positive T lymphocytes upon treatment of RA patients with TNF-alpha inhibitors. Aeberli, D., Seitz, M., Jüni, P., Villiger, P.M. Rheumatology (Oxford, England) (2005)
- Interleukin-4 promotes human CD8 T cell expression of CCR7. Seneviratne, S.L., Black, A.P., Jones, L., di Gleria, K., Bailey, A.S., Ogg, G.S. Immunology (2007)
- Tumor-infiltrating lymphocytes isolated from a Ki-1-positive large cell lymphoma of the skin. Phenotypic characterization and analysis of cytokine secretion. Reinhold, U., Abken, H., Kukel, S., Goeden, B., Uerlich, M., Neumann, U., Kreysel, H.W. Cancer (1991)
- Appropriate developmental expression of human CD8 beta in transgenic mice. Kieffer, L.J., Yan, L., Hanke, J.H., Kavathas, P.B. J. Immunol. (1997)
- The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Janeway, C.A. Annu. Rev. Immunol. (1992)
- Distinctive polymorphism at the HLA-C locus: implications for the expression of HLA-C. Zemmour, J., Parham, P. J. Exp. Med. (1992)
- A second subunit of CD8 is expressed in human T cells. Norment, A.M., Littman, D.R. EMBO J. (1988)
- The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. Barber, E.K., Dasgupta, J.D., Schlossman, S.F., Trevillyan, J.M., Rudd, C.E. Proc. Natl. Acad. Sci. U.S.A. (1989)
- Extrathymic generation of tumor-specific T cells from genetically engineered human hematopoietic stem cells via Notch signaling. Zhao, Y., Parkhurst, M.R., Zheng, Z., Cohen, C.J., Riley, J.P., Gattinoni, L., Restifo, N.P., Rosenberg, S.A., Morgan, R.A. Cancer Res. (2007)
- Isolation of the gene encoding the human T-lymphocyte differentiation antigen Leu-2 (T8) by gene transfer and cDNA subtraction. Kavathas, P., Sukhatme, V.P., Herzenberg, L.A., Parnes, J.R. Proc. Natl. Acad. Sci. U.S.A. (1984)
- Targeting of gliadin peptides, CD8, alpha/beta-TCR, and gamma/delta-TCR to Golgi complexes and vacuoles within celiac disease enterocytes. Zimmer, K.P., Naim, H., Weber, P., Ellis, H.J., Ciclitira, P.J. FASEB J. (1998)
- Prolonged expression of high molecular mass CD45RA isoform during the differentiation of human progenitor thymocytes to CD3+ cells in vitro. Deans, J.P., Wilkins, J.A., Caixia, S., Pruski, E., Pilarski, L.M. J. Immunol. (1991)
- Molecular requirements for lineage commitment in the thymus--antibody-mediated receptor engagements reveal a central role for lck in lineage decisions. Basson, M.A., Bommhardt, U., Mee, P.J., Tybulewicz, V.L., Zamoyska, R. Immunol. Rev. (1998)