The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

In-vitro activity of mupirocin ('pseudomonic acid') against clinical isolates of Staphylococcus aureus.

The in-vitro activity of mupirocin ('pseudomonic acid') was determined against clinical isolates of Staphylococcus aureus with various antibiotic resistance patterns including resistance to methicillin. All 750 isolates were inhibited by 2 mg/l of mupirocin and the MICs for 200 isolates tested on DST agar at pH 7.2 with an inoculum of 10(4) cfu ranged from 0.015 to 0.06 mg/l. Inoculum size, pH, test agar and the method of dissolving mupirocin all influenced the MICs obtained. The minimum concentrations of mupirocin to obtain a 99, and 99.9 and 99.99% kill after 24 h in Iso-Sensitest broth at pH 7.2 were 2-4, 16 and 32 mg/l, respectively. Sterile cultures were obtained when each of five strains were exposed to 1.0 mg/l or more of mupirocin for 120 h. Resistant variants with MICs of up to 4 mg/l were detected at a frequency of approximately 1 X 10(-9) and produced chrome-yellow colonies. Each of five strains could be trained to grow in the presence of 40 mg/l of mupirocin. We conclude that although apparently bacteriostatic, mupirocin has slow bactericidal activity against Staph. aureus and that 2% mupirocin may well be effective for topical treatment of skin infections caused by Staph. aureus and contribute to the control of multiply-resistant strains during hospital outbreaks.[1]

References

 
WikiGenes - Universities