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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Double-blind study of oral gamma-vinyl GABA in the treatment of dystonia.

Six patients with different forms of dystonia were treated with gamma-vinyl GABA, a specific enzyme-activated inhibitor of GABA-transaminase, in a double-blind, placebo-controlled crossover study. gamma-Vinyl GABA therapy, 2 g daily for 2 weeks, was compared with placebo by weekly assessments. There were no consistent changes in three evaluation scores. Agents that augment CNS GABA are unlikely to benefit patients with generalized dystonia.[1]

References

  1. Double-blind study of oral gamma-vinyl GABA in the treatment of dystonia. Carella, F., Girotti, F., Scigliano, G., Caraceni, T., Joder-Ohlenbusch, A.M., Schechter, P.J. Neurology (1986) [Pubmed]
 
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