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Gene Review

ABAT  -  4-aminobutyrate aminotransferase

Homo sapiens

Synonyms: (S)-3-amino-2-methylpropionate transaminase, 4-aminobutyrate aminotransferase, mitochondrial, GABA aminotransferase, GABA transaminase, GABA-AT, ...
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Disease relevance of ABAT


Psychiatry related information on ABAT


High impact information on ABAT


Chemical compound and disease context of ABAT


Biological context of ABAT


Anatomical context of ABAT


Associations of ABAT with chemical compounds


Other interactions of ABAT


Analytical, diagnostic and therapeutic context of ABAT


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  12. Candidate-gene screening and association analysis at the autism-susceptibility locus on chromosome 16p: evidence of association at GRIN2A and ABAT. Barnby, G., Abbott, A., Sykes, N., Morris, A., Weeks, D.E., Mott, R., Lamb, J., Bailey, A.J., Monaco, A.P. Am. J. Hum. Genet. (2005) [Pubmed]
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  19. Site-directed mutagenesis of human brain GABA transaminase: lysine-357 is involved in cofactor binding at the active site. Kim, D.W., Yoon, C.S., Eum, W.S., Lee, B.R., An, J.J., Lee, S.H., Lee, S.R., Ahn, J.Y., Kwon, O.S., Kang, T.C., Won, M.H., Cho, S.W., Lee, K.S., Park, J., Choi, S.Y. Mol. Cells (2004) [Pubmed]
  20. Trends in ipecac use: a survey of poison center staff. Marchbanks, B., Lockman, P., Shum, S., Beard, D. Veterinary and human toxicology. (1999) [Pubmed]
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  22. The GABA shunt: an attractive and potential therapeutic target in the treatment of epileptic disorders. Yogeeswari, P., Sriram, D., Vaigundaragavendran, J. Curr. Drug Metab. (2005) [Pubmed]
  23. gamma-Aminobutyric acid (GABA) metabolism in mammalian neural and nonneural tissues. Tillakaratne, N.J., Medina-Kauwe, L., Gibson, K.M. Comp. Biochem. Physiol. A Physiol. (1995) [Pubmed]
  24. 4-Aminobutyrate aminotransferase (GABA-transaminase) deficiency. Medina-Kauwe, L.K., Tobin, A.J., De Meirleir, L., Jaeken, J., Jakobs, C., Nyhan, W.L., Gibson, K.M. J. Inherit. Metab. Dis. (1999) [Pubmed]
  25. Uptake of GABA and activity of GABA-transaminase in platelets from epileptic patients. Rainesalo, S., Saransaari, P., Peltola, J., Keränen, T. Epilepsy Res. (2003) [Pubmed]
  26. Clinical aspects of the disorders of GABA metabolism in children. Pearl, P.L., Gibson, K.M. Curr. Opin. Neurol. (2004) [Pubmed]
  27. Platelet and brain GABA-transaminase and monoamine oxidase activities in patients with complex partial seizures. Kumlien, E., Sherif, F., Ge, L., Oreland, L. Epilepsy Res. (1995) [Pubmed]
  28. An enhanced serum prolactin response to TRH in the presence of GABA transaminase inhibition. Wroe, S.J., Rimmer, E., Kongola, G., John, R., Henley, R., Richens, A. Horm. Metab. Res. (1987) [Pubmed]
  29. Cysteine-321 of human brain GABA transaminase is involved in intersubunit cross-linking. Yoon, C.S., Kim, D.W., Jang, S.H., Lee, B.R., Choi, H.S., Choi, S.H., Kim, S.Y., An, J.J., Kwon, O.S., Kang, T.C., Won, M.H., Cho, S.W., Lee, K.S., Park, J., Eum, W.S., Choi, S.Y. Mol. Cells (2004) [Pubmed]
  30. Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin. Storici, P., De Biase, D., Bossa, F., Bruno, S., Mozzarelli, A., Peneff, C., Silverman, R.B., Schirmer, T. J. Biol. Chem. (2004) [Pubmed]
  31. Double-blind study of oral gamma-vinyl GABA in the treatment of dystonia. Carella, F., Girotti, F., Scigliano, G., Caraceni, T., Joder-Ohlenbusch, A.M., Schechter, P.J. Neurology (1986) [Pubmed]
  32. Biochemical and clinical effects of gamma-vinyl GABA in patients with epilepsy. Schechter, P.J., Hanke, N.F., Grove, J., Huebert, N., Sjoerdsma, A. Neurology (1984) [Pubmed]
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