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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

The effects of methaqualone on the seizure susceptibility of mice.

Methaqualone produces dose- and time-dependent decreases in susceptibility to electrically, chemically, and sound-induced seizures. The antagonism of methaqualone to electroconvulsive shock can be dissociated from its effects on temperature regulation and plasma corticosterone. Studies with SKF525A, a drug known to block enzymes in the liver that metabolize drugs, suggest that methaqualone, rather than a metabolite produced in the liver, is responsible for its anticonvulsant effects. Tolerance to the anticonvulsant effects of methaqualone is also demonstrated.[1]

References

  1. The effects of methaqualone on the seizure susceptibility of mice. Boggan, W.O., Meyer, J.S., Steinberg, R.M., Worthington, C. Psychopharmacology (Berl.) (1977) [Pubmed]
 
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