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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Determinants of plasma uric acid.

Obesity, alcohol consumption, and hematocrit provide an index of plasma uric acid, which in path analysis has a cultural heritability of 0.11 in children and 0.23 in parents, a small maternal effect, and a genetic heritability of 0.25 in both generations. Preliminary evidence for a major locus is destroyed by the omission of one exceptional child. There is no evidence against the polygenic hypothesis for hyperuricemia in the Japanese-American population studied.[1]

References

  1. Determinants of plasma uric acid. Gulbrandsen, C.L., Morton, N.E., Rao, D.C., Rhoads, G.G., Kagan, A. Hum. Genet. (1979) [Pubmed]
 
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