The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Asian Americans

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Asian Americans

  • Ethnic-specific incidence rates of breast cancer in the migrating generation were clearly elevated above those in the countries of origin, while rates in Asian-Americans born in the West approximated the U.S. White rate [1].
  • CONCLUSIONS: The lower nicotine (and, therefore, tobacco smoke) intake per cigarette and the fewer cigarettes smoked per day, which may result, in part, from slower clearance of nicotine, may explain lower lung cancer rates in Chinese-Americans [2].
  • METHODS: Japanese-American men aged 40-85 years and native Japanese men aged 40-89 years with no history of prostate cancer provided sera, respectively, in the United States from March 1990 through March 1992 (n = 237) or in Japan from January 1992 through December 1993 (n = 3522) [3].
  • EBV, early antigen, and anti-diffuse titers of Chinese-American and black patients with NPC were higher than those of white patients with NPC [4].
  • Sudden death, impaired glucose tolerance, and diabetes in Japanese American men [5].

Psychiatry related information on Asian Americans


High impact information on Asian Americans


Chemical compound and disease context of Asian Americans


Biological context of Asian Americans


Anatomical context of Asian Americans


Associations of Asian Americans with chemical compounds


Gene context of Asian Americans

  • All 14 were Asian-American (AA) variants and, of 11 sub-classified, 6 were AA-a and 5 AA-c. Two E1/E2-negative tumors also contained the AA-c variant, while the remaining HPV16-positive tumors contained only European variants [25].
  • In multivariate models, compared with Caucasian women, Asian Americans had 22% higher calculated free estradiol (P < 0.01), 31% lower SHBG (P < 0.01), and 25% higher free IGF-I (P < 0.01) levels [26].
  • These results demonstrate the presence of both genetic and environmental effects on CRP levels among Asian Americans, and additional studies are needed to determine if the APOE gene contributes to these genetic influences [27].
  • Recent epidemiological studies in Japanese-Americans and in Omagari area where HALP subjects with the intron 14 splicing defect of CETP gene are markedly frequent, have demonstrated an increased incidence of coronary atherosclerosis in CETP-deficient patients [28].
  • Insulin-receptor and apolipoprotein genes contribute to development of NIDDM in Chinese Americans [29].

Analytical, diagnostic and therapeutic context of Asian Americans


  1. Migration patterns and breast cancer risk in Asian-American women. Ziegler, R.G., Hoover, R.N., Pike, M.C., Hildesheim, A., Nomura, A.M., West, D.W., Wu-Williams, A.H., Kolonel, L.N., Horn-Ross, P.L., Rosenthal, J.F., Hyer, M.B. J. Natl. Cancer Inst. (1993) [Pubmed]
  2. Slower metabolism and reduced intake of nicotine from cigarette smoking in Chinese-Americans. Benowitz, N.L., Pérez-Stable, E.J., Herrera, B., Jacob, P. J. Natl. Cancer Inst. (2002) [Pubmed]
  3. Serum levels of prostate-specific antigen among Japanese-American and native Japanese men. Shibata, A., Whittemore, A.S., Imai, K., Kolonel, L.N., Wu, A.H., John, E.M., Stamey, T.A., Paffenbarger, R.S. J. Natl. Cancer Inst. (1997) [Pubmed]
  4. Epstein-Barr virus and nasopharyngeal carcinoma: is there an etiologic relationship? Henderson, B.E., Louie, E.W., Jing, J.S., Alena, B. J. Natl. Cancer Inst. (1977) [Pubmed]
  5. Sudden death, impaired glucose tolerance, and diabetes in Japanese American men. Curb, J.D., Rodriguez, B.L., Burchfiel, C.M., Abbott, R.D., Chiu, D., Yano, K. Circulation (1995) [Pubmed]
  6. A presenilin-1 mutation (T245P) in transmembrane domain 6 causes early onset Alzheimer's disease. Edwards-Lee, T., Wen, J., Bell, J., Hardy, J., Chung, J., Momeni, P. Neurosci. Lett. (2006) [Pubmed]
  7. Asian Americans and standards of attractiveness: what's in the eye of the beholder? Mok, T.A. Cultural diversity and mental health. (1998) [Pubmed]
  8. Asian American-white American differences in expressions of social anxiety: a replication and extension. Okazaki, S., Liu, J.F., Longworth, S.L., Minn, J.Y. Cultural diversity & ethnic minority psychology. (2002) [Pubmed]
  9. Prevalence of dementia in older Japanese-American men in Hawaii: The Honolulu-Asia Aging Study. White, L., Petrovitch, H., Ross, G.W., Masaki, K.H., Abbott, R.D., Teng, E.L., Rodriguez, B.L., Blanchette, P.L., Havlik, R.J., Wergowske, G., Chiu, D., Foley, D.J., Murdaugh, C., Curb, J.D. JAMA (1996) [Pubmed]
  10. Serum total cholesterol and mortality. Confounding factors and risk modification in Japanese-American men. Iribarren, C., Reed, D.M., Burchfiel, C.M., Dwyer, J.H. JAMA (1995) [Pubmed]
  11. Alcohol metabolism in Asian-American men with genetic polymorphisms of aldehyde dehydrogenase. Wall, T.L., Peterson, C.M., Peterson, K.P., Johnson, M.L., Thomasson, H.R., Cole, M., Ehlers, C.L. Ann. Intern. Med. (1997) [Pubmed]
  12. Stevens-Johnson syndrome associated with methazolamide treatment reported in two Japanese-American women. Flach, A.J., Smith, R.E., Fraunfelder, F.T. Ophthalmology (1995) [Pubmed]
  13. Low-density lipoprotein particle size, triglycerides, and high-density lipoprotein cholesterol as risk factors for coronary heart disease in older Japanese-American men. Austin, M.A., Rodriguez, B.L., McKnight, B., McNeely, M.J., Edwards, K.L., Curb, J.D., Sharp, D.S. Am. J. Cardiol. (2000) [Pubmed]
  14. Patterns of linkage disequilibrium in the type 2 diabetes gene calpain-10. Hayes, M.G., Del Bosque-Plata, L., Tsuchiya, T., Hanis, C.L., Bell, G.I., Cox, N.J. Diabetes (2005) [Pubmed]
  15. Elevated C-reactive protein is a risk factor for the development of type 2 diabetes in Japanese Americans. Nakanishi, S., Yamane, K., Kamei, N., Okubo, M., Kohno, N. Diabetes Care (2003) [Pubmed]
  16. Improvement of BMI, body composition, and body fat distribution with lifestyle modification in Japanese Americans with impaired glucose tolerance. Liao, D., Asberry, P.J., Shofer, J.B., Callahan, H., Matthys, C., Boyko, E.J., Leonetti, D., Kahn, S.E., Austin, M., Newell, L., Schwartz, R.S., Fujimoto, W.Y. Diabetes Care (2002) [Pubmed]
  17. Earlier appearance of impaired insulin secretion than of visceral adiposity in the pathogenesis of NIDDM. 5-Year follow-up of initially nondiabetic Japanese-American men. Chen, K.W., Boyko, E.J., Bergstrom, R.W., Leonetti, D.L., Newell-Morris, L., Wahl, P.W., Fujimoto, W.Y. Diabetes Care (1995) [Pubmed]
  18. Glucokinase gene variations in Japanese-Americans with a family history of NIDDM. Stone, L.M., Kahn, S.E., Deeb, S.S., Fujimoto, W.Y., Porte, D. Diabetes Care (1994) [Pubmed]
  19. Low serum testosterone level as a predictor of increased visceral fat in Japanese-American men. Tsai, E.C., Boyko, E.J., Leonetti, D.L., Fujimoto, W.Y. Int. J. Obes. Relat. Metab. Disord. (2000) [Pubmed]
  20. Prevalence of complications among second-generation Japanese-American men with diabetes, impaired glucose tolerance, or normal glucose tolerance. Fujimoto, W.Y., Leonetti, D.L., Kinyoun, J.L., Shuman, W.P., Stolov, W.C., Wahl, P.W. Diabetes (1987) [Pubmed]
  21. Postmenopausal estrogen and estrogen-progestin use and 2-year rate of cognitive change in a cohort of older Japanese American women: The Kame Project. Rice, M.M., Graves, A.B., McCurry, S.M., Gibbons, L.E., Bowen, J.D., McCormick, W.C., Larson, E.B. Arch. Intern. Med. (2000) [Pubmed]
  22. Distribution and correlates of lipids and lipoproteins in elderly Japanese-American men. The Honolulu Heart Program. Burchfiel, C.M., Abbott, R.D., Sharp, D.S., Curb, J.D., Rodriguez, B.L., Yano, K. Arterioscler. Thromb. Vasc. Biol. (1996) [Pubmed]
  23. Lactose digestion and tolerance in adult and elderly Asian-Americans. Suarez, F.L., Savaiano, D.A. Am. J. Clin. Nutr. (1994) [Pubmed]
  24. Type 2 diabetes prevalence in Asian Americans: results of a national health survey. McNeely, M.J., Boyko, E.J. Diabetes Care (2004) [Pubmed]
  25. Asian-american variants of human papillomavirus type 16 have extensive mutations in the E2 gene and are highly amplified in cervical carcinomas. Casas, L., Galvan, S.C., Ordoñez, R.M., Lopez, N., Guido, M., Berumen, J. Int. J. Cancer (1999) [Pubmed]
  26. Racial differences in premenopausal endogenous hormones. Pinheiro, S.P., Holmes, M.D., Pollak, M.N., Barbieri, R.L., Hankinson, S.E. Cancer Epidemiol. Biomarkers Prev. (2005) [Pubmed]
  27. Heritability of C-reactive protein and association with apolipoprotein E genotypes in Japanese Americans. Austin, M.A., Zhang, C., Humphries, S.E., Chandler, W.L., Talmud, P.J., Edwards, K.L., Leonetti, D.L., McNeely, M.J., Fujimoto, W.Y. Ann. Hum. Genet. (2004) [Pubmed]
  28. Roles of plasma lipid transfer proteins in reverse cholesterol transport. Yamashita, S., Sakai, N., Hirano , K., Ishigami, M., Maruyama, T., Nakajima, N., Matsuzawa, Y. Front. Biosci. (2001) [Pubmed]
  29. Insulin-receptor and apolipoprotein genes contribute to development of NIDDM in Chinese Americans. Xiang, K.S., Cox, N.J., Sanz, N., Huang, P., Karam, J.H., Bell, G.I. Diabetes (1989) [Pubmed]
  30. Reference values for pulmonary function tests of Japanese-American men aged 71 to 90 years. Sharp, D.S., Enright, P.L., Chiu, D., Burchfiel, C.M., Rodriguez, B.L., Curb, J.D. Am. J. Respir. Crit. Care Med. (1996) [Pubmed]
  31. Molecular mechanisms, lipoprotein abnormalities and atherogenicity of hyperalphalipoproteinemia. Yamashita, S., Maruyama, T., Hirano, K., Sakai, N., Nakajima, N., Matsuzawa, Y. Atherosclerosis (2000) [Pubmed]
  32. Does mammographic density reflect ethnic differences in breast cancer incidence rates? Chen, Z., Wu, A.H., Gauderman, W.J., Bernstein, L., Ma, H., Pike, M.C., Ursin, G. Am. J. Epidemiol. (2004) [Pubmed]
  33. Relationship between development of diabetes and family history by gender in Japanese-Americans. Nakanishi, S., Yamane, K., Kamei, N., Okubo, M., Kohno, N. Diabetes Res. Clin. Pract. (2003) [Pubmed]
  34. Human papillomavirus may be common within nasopharyngeal carcinoma of Caucasian Americans: investigation of Epstein-Barr virus and human papillomavirus in eastern and western nasopharyngeal carcinoma using ligation-dependent polymerase chain reaction. Punwaney, R., Brandwein, M.S., Zhang, D.Y., Urken, M.L., Cheng, R., Park, C.S., Li, H.B., Li, X. Head & neck. (1999) [Pubmed]
WikiGenes - Universities