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McDonagh, A.F. et al.

Jaundice phototherapy: micro flow-cell photometry reveals rapid biliary response of Gunn rats to light.

Hepatic pigment clearance in rats can be followed continuously with photometric detectors designed for high-pressure liquid chromatography. This method showed that light has a fast effect on bilirubin metabolism in homozygous Gunn rats, even at low doses and intensities. This is consistent with geometric isomerization of bilirubin IXalpha as a primary step in phototherapy.[1]

References

Jaundice phototherapy: micro flow-cell photometry reveals rapid biliary response of Gunn rats to light. McDonagh, A.F., Ramonas, L.M. Science (1978) [Pubmed]

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