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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Phototherapy


Psychiatry related information on Phototherapy


High impact information on Phototherapy


Chemical compound and disease context of Phototherapy


Biological context of Phototherapy


Anatomical context of Phototherapy


Associations of Phototherapy with chemical compounds

  • Photobilirubin II is the unidentified major photoderivative described previously, whereas formation of photobilirubins IA and IB, and their reversion to bilirubin-IXalpha, account for the remarkably increased output of the parent pigment during phototherapy [31].
  • The group included 5 patients with type I disease who were all treated with phototherapy and 6 patients with type II disease who were primarily treated with phenobarbital [32].
  • Phototherapy initially increased biliary specific activity of both primary bile acids and then produced an acceleration of cholic and chenodeoxycholic acid decay curves [33].
  • CONCLUSIONS: Rapid tryptophan depletion appears to reverse the antidepressant effect of bright light therapy in patients with SAD [34].
  • These findings confirm previous work showing that serotonin plays an important role in the mechanism of action of light therapy and provide new evidence that brain catecholaminergic systems may also be involved [6].

Gene context of Phototherapy

  • We first determined the sequences of promoter and all coding regions of the heme oxygenase-1 gene in Japanese neonates who had undergone phototherapy, but found no mutation except for the polymorphic (GT)n repeats in the promoter region [35].
  • Phototherapy caused a 70% increase in IL-2 secretion (123 +/- 27 vs 208 +/- 30 units/ml, P < 0.01) and 56% in IL-10 production (1.07 +/- 0.19 vs 1.67 +/- 0.33 ng/ml, P < 0. 03), whereas the spontaneous secretion of IL-1beta was reduced by 43% (13.7 +/- 2.3 vs 7.3 +/- 1.7 ng/ml, P < 0.02) [30].
  • Increased stool number was noted in infants in group C. Increased VIP levels in jaundiced infants under phototherapy may be the cause of increased stool frequency, through stimulation of intestinal water and electrolyte secretion [36].
  • A sample of children treated by phototherapy during the neonatal period has been studied in the population of Penne (South Eastern Italy) in order to confirm the association previously reported in newborns from the population of Rome between neonatal jaundice and phenotypes of adenosine deaminase (ADA) and acid phosphatase (ACP1) [37].
  • The amounts of IgG1, -2, -3 and -4 and IgE in the plasma of the patients did not vary with either of the two phototherapies [38].

Analytical, diagnostic and therapeutic context of Phototherapy


  1. Effective oral treatment of unconjugated hyperbilirubinemia in Gunn rats. Hafkamp, A.M., Havinga, R., Sinaasappel, M., Verkade, H.J. Hepatology (2005) [Pubmed]
  2. Psoriasis: current perspectives with an emphasis on treatment. Linden, K.G., Weinstein, G.D. Am. J. Med. (1999) [Pubmed]
  3. Seasonal bulimia treated with fluoxetine and phototherapy. Schwitzer, J., Neudorfer, C., Fleischhacker, W.W. The American journal of psychiatry. (1993) [Pubmed]
  4. Neonatal bilirubin toxicity. A review of kernicterus and the implications of drug-induced bilirubin displacement. Walker, P.C. Clinical pharmacokinetics. (1987) [Pubmed]
  5. Orthotopic liver transplantation for Crigler-Najjar type I disease in six children. Sokal, E.M., Silva, E.S., Hermans, D., Reding, R., de Ville de Goyet, J., Buts, J.P., Otte, J.B. Transplantation (1995) [Pubmed]
  6. Effects of tryptophan depletion vs catecholamine depletion in patients with seasonal affective disorder in remission with light therapy. Neumeister, A., Turner, E.H., Matthews, J.R., Postolache, T.T., Barnett, R.L., Rauh, M., Vetticad, R.G., Kasper, S., Rosenthal, N.E. Arch. Gen. Psychiatry (1998) [Pubmed]
  7. Antidepressant effects of light therapy combined with sleep deprivation are influenced by a functional polymorphism within the promoter of the serotonin transporter gene. Benedetti, F., Colombo, C., Serretti, A., Lorenzi, C., Pontiggia, A., Barbini, B., Smeraldi, E. Biol. Psychiatry (2003) [Pubmed]
  8. Practice parameters for the use of light therapy in the treatment of sleep disorders. Standards of Practice Committee, American Academy of Sleep Medicine. Chesson, A.L., Littner, M., Davila, D., Anderson, W.M., Grigg-Damberger, M., Hartse, K., Johnson, S., Wise, M. Sleep. (1999) [Pubmed]
  9. Non-antidepressant treatment of premenstrual syndrome. Pearlstein, T., Steiner, M. The Journal of clinical psychiatry. (2000) [Pubmed]
  10. Phototherapy for neonatal hyperbilirubinemia: six-year follow-up of the National Institute of Child Health and Human Development clinical trial. Scheidt, P.C., Bryla, D.A., Nelson, K.B., Hirtz, D.G., Hoffman, H.J. Pediatrics (1990) [Pubmed]
  11. Relief of uremic pruritus with ultraviolet phototherapy. Gilchrest, B.A., Rowe, J.W., Brown, R.S., Steinman, T.I., Arndt, K.A. N. Engl. J. Med. (1977) [Pubmed]
  12. No evidence of lactase deficiency related to phototherapy of jaundiced infants. Chung, C.M., Kong, Y.F. N. Engl. J. Med. (1976) [Pubmed]
  13. Chronobiologists out of sync over light therapy patents. Nowak, R. Science (1994) [Pubmed]
  14. Jaundice phototherapy: micro flow-cell photometry reveals rapid biliary response of Gunn rats to light. McDonagh, A.F., Ramonas, L.M. Science (1978) [Pubmed]
  15. Effect of prolonged illumination (phototherapy) on concentrations of luteinizing hormone in human infants. Dacou-Voutetakis, C., Anagnostakis, D., Matsaniotis, N. Science (1978) [Pubmed]
  16. Circadian profiles of cortisol, prolactin, and thyrotropin in seasonal affective disorder. Oren, D.A., Levendosky, A.A., Kasper, S., Duncan, C.C., Rosenthal, N.E. Biol. Psychiatry (1996) [Pubmed]
  17. Growth hormone response to sumatriptan (5-HT1D agonist) challenge in seasonal affective disorder: effects of light therapy. Yatham, L.N., Lam, R.W., Zis, A.P. Biol. Psychiatry (1997) [Pubmed]
  18. Photopic and scotopic light detection in patients with seasonal affective disorder and control subjects. Terman, J.S., Terman, M. Biol. Psychiatry (1999) [Pubmed]
  19. The lack of effects of phototherapy on neonatal oxygen dissociation curves and hemoglobin concentration in vivo. Chandler, B.D., Cashore, W.J., Monin, P.J., Oh, W. Pediatrics (1977) [Pubmed]
  20. Melatonin in seasonal affective disorder and phototherapy. Rosenthal, N.E., Sack, D.A., Jacobsen, F.M., James, S.P., Parry, B.L., Arendt, J., Tamarkin, L., Wehr, T.A. J. Neural Transm. Suppl. (1986) [Pubmed]
  21. The human pineal gland and melatonin in aging and Alzheimer's disease. Wu, Y.H., Swaab, D.F. J. Pineal Res. (2005) [Pubmed]
  22. Influence of phototherapy on the pharmacokinetics of gentamicin. Papadatos, J., Kafetzis, D., Papadatos, C. J. Infect. Dis. (1982) [Pubmed]
  23. Photoinactivation of T-cell function with psoralen and UVA radiation suppresses the induction of experimental murine graft-versus-host disease across major histocompatibility barriers. Ullrich, S.E. J. Invest. Dermatol. (1991) [Pubmed]
  24. Transcutaneous bilirubinometry II. Dermal bilirubin kinetics during phototherapy. Hegyi, T., Hiatt, I.M., Gertner, I.M., Zanni, R., Tolentino, T. Pediatr. Res. (1983) [Pubmed]
  25. Bilirubin photoisomerization in premature neonates under low- and high-dose phototherapy. Costarino, A.T., Ennever, J.F., Baumgart, S., Speck, W.T., Paul, M., Polin, R.A. Pediatrics (1985) [Pubmed]
  26. The effects of seasons and light therapy on G protein levels in mononuclear leukocytes of patients with seasonal affective disorder. Avissar, S., Schreiber, G., Nechamkin, Y., Neuhaus, I., Lam, G.K., Schwartz, P., Turner, E., Matthews, J., Naim, S., Rosenthal, N.E. Arch. Gen. Psychiatry (1999) [Pubmed]
  27. Ultrastructural changes of bladder cancer cells following methylene blue-sensitized photodynamic treatment. Yu, D.S., Chang, S.Y., Ma, C.P. Eur. Urol. (1991) [Pubmed]
  28. Effect of phototherapy on serum bilirubin levels and red blood cell survival in congenitally jaundiced Gunn rats. Howe, R.B., Hadland, C.R., Engel, R.R. J. Lab. Clin. Med. (1978) [Pubmed]
  29. Phototherapy: the cause of increased enterohepatic circulation of bilirubin in newborn infants? Jirsová, V., Hodr, R. Biol. Neonate (1979) [Pubmed]
  30. Phototherapy for neonatal hyperbilirubinemia affects cytokine production by peripheral blood mononuclear cells. Sirota, L., Straussberg, R., Gurary, N., Aloni, D., Bessler, H. Eur. J. Pediatr. (1999) [Pubmed]
  31. Excretion of administered and endogenous photobilirubins in the bile of the jaundice gunn rat. Stoll, M.S., Zenone, E.A., Ostrow, J.D. J. Clin. Invest. (1981) [Pubmed]
  32. Oral calcium phosphate: a new therapy for Crigler-Najjar disease? Van der Veere, C.N., Jansen, P.L., Sinaasappel, M., Van der Meer, R., Van der Sijs, H., Rammeloo, J.A., Goyens, P., Van Nieuwkerk, C.M., Oude Elferink, R.P. Gastroenterology (1997) [Pubmed]
  33. Effects of phototherapy on hepatic function in human alcoholic cirrhosis. Knodell, R.G., Cheney, H., Ostrow, J.D. Gastroenterology (1976) [Pubmed]
  34. Effects of rapid tryptophan depletion in patients with seasonal affective disorder in remission after light therapy. Lam, R.W., Zis, A.P., Grewal, A., Delgado, P.L., Charney, D.S., Krystal, J.H. Arch. Gen. Psychiatry (1996) [Pubmed]
  35. Neonatal hyperbilirubinemia in Japanese neonates: analysis of the heme oxygenase-1 gene and fetal hemoglobin composition in cord blood. Kanai, M., Akaba, K., Sasaki, A., Sato, M., Harano, T., Shibahara, S., Kurachi, H., Yoshida, T., Hayasaka, K. Pediatr. Res. (2003) [Pubmed]
  36. Gut hormone levels in neonates under phototherapy. Gounaris, A., Alexiou, N., Costalos, C., Daniilidou, M., Bakoleas, V., Constantellou, E. Early Hum. Dev. (1998) [Pubmed]
  37. Enzyme variability and neonatal jaundice. The role of adenosine deaminase and acid phosphatase. Lepore, A., Lucarini, N., Evangelista, M.A., Palombaro, G., Londrillo, A., Ballarini, P., Borgiani, P., Gloria-Bottini, F., Bottini, E. Journal of perinatal medicine. (1989) [Pubmed]
  38. Effects of phototherapy on the production of cytokines by peripheral blood mononuclear cells and on systemic antibody responses in patients with psoriasis. Jones, C.D., Guckian, M., el-Ghorr, A.A., Gibbs, N.K., Norval, M. Photodermatology, photoimmunology & photomedicine. (1996) [Pubmed]
  39. Delayed sleep phase syndrome: pathophysiology and treatment options. Wyatt, J.K. Sleep. (2004) [Pubmed]
  40. Green light phototherapy in newborn infants with ABO hemolytic disease. Ayyash, H., Hadjigeorgiou, E., Sofatzis, J., Chatziioannou, A., Nicolopoulos, D., Sideris, E. J. Pediatr. (1987) [Pubmed]
  41. The separation of configurational isomers of bilirubin by high pressure liquid chromatography and the mechanism of jaundice phototherapy. Onishi, S., Itoh, S., Kawade, N., Isobe, K., Sugiyama, S. Biochem. Biophys. Res. Commun. (1979) [Pubmed]
  42. Ibuprofen in the treatment of UV-B-induced inflammation. Stern, R.S., Dodson, T.B. Archives of dermatology. (1985) [Pubmed]
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