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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Phototherapy

 
 
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Disease relevance of Phototherapy

 

Psychiatry related information on Phototherapy

 

High impact information on Phototherapy

 

Chemical compound and disease context of Phototherapy

 

Biological context of Phototherapy

 

Anatomical context of Phototherapy

 

Associations of Phototherapy with chemical compounds

  • Photobilirubin II is the unidentified major photoderivative described previously, whereas formation of photobilirubins IA and IB, and their reversion to bilirubin-IXalpha, account for the remarkably increased output of the parent pigment during phototherapy [31].
  • The group included 5 patients with type I disease who were all treated with phototherapy and 6 patients with type II disease who were primarily treated with phenobarbital [32].
  • Phototherapy initially increased biliary specific activity of both primary bile acids and then produced an acceleration of cholic and chenodeoxycholic acid decay curves [33].
  • CONCLUSIONS: Rapid tryptophan depletion appears to reverse the antidepressant effect of bright light therapy in patients with SAD [34].
  • These findings confirm previous work showing that serotonin plays an important role in the mechanism of action of light therapy and provide new evidence that brain catecholaminergic systems may also be involved [6].
 

Gene context of Phototherapy

  • We first determined the sequences of promoter and all coding regions of the heme oxygenase-1 gene in Japanese neonates who had undergone phototherapy, but found no mutation except for the polymorphic (GT)n repeats in the promoter region [35].
  • Phototherapy caused a 70% increase in IL-2 secretion (123 +/- 27 vs 208 +/- 30 units/ml, P < 0.01) and 56% in IL-10 production (1.07 +/- 0.19 vs 1.67 +/- 0.33 ng/ml, P < 0. 03), whereas the spontaneous secretion of IL-1beta was reduced by 43% (13.7 +/- 2.3 vs 7.3 +/- 1.7 ng/ml, P < 0.02) [30].
  • Increased stool number was noted in infants in group C. Increased VIP levels in jaundiced infants under phototherapy may be the cause of increased stool frequency, through stimulation of intestinal water and electrolyte secretion [36].
  • A sample of children treated by phototherapy during the neonatal period has been studied in the population of Penne (South Eastern Italy) in order to confirm the association previously reported in newborns from the population of Rome between neonatal jaundice and phenotypes of adenosine deaminase (ADA) and acid phosphatase (ACP1) [37].
  • The amounts of IgG1, -2, -3 and -4 and IgE in the plasma of the patients did not vary with either of the two phototherapies [38].
 

Analytical, diagnostic and therapeutic context of Phototherapy

References

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  24. Transcutaneous bilirubinometry II. Dermal bilirubin kinetics during phototherapy. Hegyi, T., Hiatt, I.M., Gertner, I.M., Zanni, R., Tolentino, T. Pediatr. Res. (1983) [Pubmed]
  25. Bilirubin photoisomerization in premature neonates under low- and high-dose phototherapy. Costarino, A.T., Ennever, J.F., Baumgart, S., Speck, W.T., Paul, M., Polin, R.A. Pediatrics (1985) [Pubmed]
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  32. Oral calcium phosphate: a new therapy for Crigler-Najjar disease? Van der Veere, C.N., Jansen, P.L., Sinaasappel, M., Van der Meer, R., Van der Sijs, H., Rammeloo, J.A., Goyens, P., Van Nieuwkerk, C.M., Oude Elferink, R.P. Gastroenterology (1997) [Pubmed]
  33. Effects of phototherapy on hepatic function in human alcoholic cirrhosis. Knodell, R.G., Cheney, H., Ostrow, J.D. Gastroenterology (1976) [Pubmed]
  34. Effects of rapid tryptophan depletion in patients with seasonal affective disorder in remission after light therapy. Lam, R.W., Zis, A.P., Grewal, A., Delgado, P.L., Charney, D.S., Krystal, J.H. Arch. Gen. Psychiatry (1996) [Pubmed]
  35. Neonatal hyperbilirubinemia in Japanese neonates: analysis of the heme oxygenase-1 gene and fetal hemoglobin composition in cord blood. Kanai, M., Akaba, K., Sasaki, A., Sato, M., Harano, T., Shibahara, S., Kurachi, H., Yoshida, T., Hayasaka, K. Pediatr. Res. (2003) [Pubmed]
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