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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Expression of Thy1, TL and LYT antigens on spontaneous leukemias of BALB/MO strain of mice.

The expression of Thy1, TL and Tyt antigens on spontaneous BALB/Mo leukemias has been studied. The results obtained thus far indicate that a majority of leukemias express TL antigen and differentiated Lyt phenotype. This observation and other findings demonstrating the existence of TL+ thymocytes with different Lyt phenotypes in normal thymus of young mice lends support for the hypothesis that TL+Lyt2+ phenotype defines this stage in the T cell differentiation pathway, which is particularly sensitive to leukemic transformation.[1]

References

  1. Expression of Thy1, TL and LYT antigens on spontaneous leukemias of BALB/MO strain of mice. Strzadała, L., Opolski, A., Kisielow, P. Arch. Immunol. Ther. Exp. (Warsz.) (1981) [Pubmed]
 
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