The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

About

Terms

 

 
 

Effects of the constituents of a corticosteroid enema preparation on colonic blood flow and oxygen uptake in the dog.

A number of currently available therapeutic agents for the management of idiopathic inflammatory bowel disease were studied with respect to their influence on blood flow and oxygen extraction in the dog colon. Some commercially available corticosteroid enemas including Cortenema and its vehicle and sulfasalazine and its split products were delivered intraluminally while arterial pressure, blood flow and oxygen extraction in autoperfused segments of the colon were continuously monitored. Of the agents studied, only Cortenema and its vehicle exerted any appreciable effect on colonic blood flow, producing a sustained 50% increase; this increase in blood flow was confined to the mucosa-submucosal layer. Of the constituents of Cortenema, methylparaben was responsible for 72% of the hyperemia whereas the remainder was due to carboxypolymethylene. The corticosteroid itself had no effect. Oxygen uptake by the colon was reduced by approximately 10% with Cortenema, this reduction being due entirely to polysorbate 80. In vitro analysis of the oxygen uptake effect indicates that the enema exerts a direct metabolic action.[1]

References

  1. Effects of the constituents of a corticosteroid enema preparation on colonic blood flow and oxygen uptake in the dog. Barrowman, J.A., Kvietys, P.R., Granger, D.N., McElearney, P.M., Perry, M.A. J. Pharmacol. Exp. Ther. (1983) [Pubmed]
Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities