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Disease relevance of Hyperemia


Psychiatry related information on Hyperemia

  • BACKGROUND: The purpose of the present study was to determine interactive and main effects of the eNOS T-786C gene polymorphism and habitual physical activity level on forearm vascular resistance (FVR) and forearm blood flow (FBF) at rest and during 3 min of reactive hyperemia [6].

High impact information on Hyperemia


Chemical compound and disease context of Hyperemia

  • Endogenous nitric oxide, H1 receptors, and capsaicin-sensitive afferent nerves are not involved in this protective hyperemia [11].
  • Within 1 min of contact, ethanol caused diffuse mucosal hyperemia [12].
  • CONCLUSIONS: Both prostacyclin and NO contributed to splanchnic hyperemia in portal-hypertensive rats [13].
  • Key mechanisms contributing to enteral nutrient-induced intestinal adaptation include nonspecific luminal stimulation and that provided by specific nutrients, "functional workload" induced by polymeric nutrients, potential stimulation of pancreaticobiliary secretions, secretion of humoral mediators, and induction of intestinal hyperemia [14].
  • The results of this study may have important implications in steatorrheal diseases in that, atropine may alleviate the diarrhea induced by the presence of excess lipid in chyme without compromising the intestinal hyperemia and enhanced oxygen delivery required to meet the increased metabolic demands during nutrient absorption [15].

Biological context of Hyperemia


Anatomical context of Hyperemia

  • Therefore, this study examines the effect of SP on capsaicin-induced mucosal hyperemia and mast cells [21].
  • Only after 1-2 days of the initial insult, were signs of classical inflammation observed, including increases in colonic myeloperoxidase activity (neutrophil infiltration) and colon weight as well as hyperemia and mucosal ulcerations [22].
  • We measured brachial artery diameters noninvasively using a 7.5-MHz ultrasound machine at rest, during reactive hyperemia, and after sublingual nitroglycerin administration [23].
  • Proximal and distal poststenotic Doppler coronary flow velocities were measured (left anterior descending coronary artery, 16; right coronary artery, 10; left circumflex artery, 7 patients) before and during peak maximal hyperemia with intracoronary adenosine (8 to 12 micrograms) [24].
  • With a recently developed high-resolution ultrasound system, diameters of radial artery were measured at rest, during reactive hyperemia (with increased flow causing endothelium-mediated dilation), and during sodium nitroprusside, causing endothelium-independent dilation [25].

Gene context of Hyperemia


Analytical, diagnostic and therapeutic context of Hyperemia


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  6. eNOS T-786C genotype, physical activity, and peak forearm blood flow in females. Data, S.A., Roltsch, M.H., Hand, B., Ferrell, R.E., Park, J.J., Brown, M.D. Medicine and science in sports and exercise. (2003) [Pubmed]
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  11. Mechanism of gastric hyperemia induced by intragastric hypertonic saline in rats. Endoh, K., Kao, J., Domek, M.J., Leung, F.W. Gastroenterology (1993) [Pubmed]
  12. Studies on the mechanism of ethanol-induced gastric damage in rats. Oates, P.J., Hakkinen, J.P. Gastroenterology (1988) [Pubmed]
  13. Acute and chronic cyclooxygenase blockage in portal-hypertensive rats: influence in nitric oxide biosynthesis. Fernández, M., García-Pagán, J.C., Casadevall, M., Mourelle, M.I., Piqué, J.M., Bosch, J., Rodés, J. Gastroenterology (1996) [Pubmed]
  14. Mechanisms of enteral nutrient-enhanced intestinal adaptation. Tappenden, K.A. Gastroenterology (2006) [Pubmed]
  15. Effect of atropine on bile-oleic acid-induced alterations in dog jejunal hemodynamics, oxygenation, and net transmucosal water movement. Kvietys, P.R., Wilborn, W.H., Granger, D.N. Gastroenterology (1981) [Pubmed]
  16. Sex differences in peripheral vascular adrenergic receptors. Freedman, R.R., Sabharwal, S.C., Desai, N. Circ. Res. (1987) [Pubmed]
  17. Guinea pig plasma kallikrein as a vascular permeability enhancement factor. Its dependence on kinin generation and regulation mechanisms in vivo. Imamura, T., Yamamoto, T., Kambara, T. Am. J. Pathol. (1984) [Pubmed]
  18. Local regulation of digital blood flow in generalized scleroderma. Kristensen, J.K. J. Invest. Dermatol. (1979) [Pubmed]
  19. Quantitation of phototoxic hyperemia and permeability to protein: II. Inhibition by histamine (H1 and H2) receptor antagonists in mouse skin. Argenbright, L.W., Forbes, P.D., Stewart, G.J. J. Invest. Dermatol. (1980) [Pubmed]
  20. Increased endothelial nitric oxide synthase activity in the hyperemic vessels of portal hypertensive rats. Cahill, P.A., Redmond, E.M., Hodges, R., Zhang, S., Sitzmann, J.V. J. Hepatol. (1996) [Pubmed]
  21. Substance P attenuates gastric mucosal hyperemia after stimulation of sensory neurons in the rat stomach. Grönbech, J.E., Lacy, E.R. Gastroenterology (1994) [Pubmed]
  22. A comparative analysis of two models of colitis in rats. Yamada, Y., Marshall, S., Specian, R.D., Grisham, M.B. Gastroenterology (1992) [Pubmed]
  23. Modulation of endothelium-dependent flow-mediated dilatation of the brachial artery by sex and menstrual cycle. Hashimoto, M., Akishita, M., Eto, M., Ishikawa, M., Kozaki, K., Toba, K., Sagara, Y., Taketani, Y., Orimo, H., Ouchi, Y. Circulation (1995) [Pubmed]
  24. Correlation of pharmacological 99mTc-sestamibi myocardial perfusion imaging with poststenotic coronary flow reserve in patients with angiographically intermediate coronary artery stenoses. Miller, D.D., Donohue, T.J., Younis, L.T., Bach, R.G., Aguirre, F.V., Wittry, M.D., Goodgold, H.M., Chaitman, B.R., Kern, M.J. Circulation (1994) [Pubmed]
  25. Physical training improves endothelial function in patients with chronic heart failure. Hornig, B., Maier, V., Drexler, H. Circulation (1996) [Pubmed]
  26. Role of inducible nitric oxide synthase and cyclooxygenase-2 in endotoxin-induced cerebral hyperemia. Okamoto, H., Ito, O., Roman, R.J., Hudetz, A.G. Stroke (1998) [Pubmed]
  27. Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. Minghetti, L. J. Neuropathol. Exp. Neurol. (2004) [Pubmed]
  28. Exogenous and endogenous cholecystokinin protects gastric mucosa against the damage caused by ethanol in rats. Konturek, S.J., Brzozowski, T., Pytko-Polonczyk, J., Drozdowicz, D. Eur. J. Pharmacol. (1995) [Pubmed]
  29. Leptin induces ovulation in GnRH-deficient mice. Barkan, D., Hurgin, V., Dekel, N., Amsterdam, A., Rubinstein, M. FASEB J. (2005) [Pubmed]
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  31. Validation of [1-11C]acetate as a tracer for noninvasive assessment of oxidative metabolism with positron emission tomography in normal, ischemic, postischemic, and hyperemic canine myocardium. Armbrecht, J.J., Buxton, D.B., Schelbert, H.R. Circulation (1990) [Pubmed]
  32. Comparison of myocardial perfusion reserve before and after coronary balloon predilatation and after stent implantation in patients with postangioplasty restenosis. Haude, M., Caspari, G., Baumgart, D., Brennecke, R., Meyer, J., Erbel, R. Circulation (1996) [Pubmed]
  33. Detection of coronary stenoses and quantification of the degree and spatial extent of blood flow mismatch during coronary hyperemia with myocardial contrast echocardiography. Ismail, S., Jayaweera, A.R., Goodman, N.C., Camarano, G.P., Skyba, D.M., Kaul, S. Circulation (1995) [Pubmed]
  34. Effects of long-term smoking on myocardial blood flow, coronary vasomotion, and vasodilator capacity. Campisi, R., Czernin, J., Schöder, H., Sayre, J.W., Marengo, F.D., Phelps, M.E., Schelbert, H.R. Circulation (1998) [Pubmed]
  35. Fractional flow reserve. A useful index to evaluate the influence of an epicardial coronary stenosis on myocardial blood flow. Pijls, N.H., Van Gelder, B., Van der Voort, P., Peels, K., Bracke, F.A., Bonnier, H.J., el Gamal, M.I. Circulation (1995) [Pubmed]
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