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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Presence of neuropeptide Y in human circle of Willis and its possible role in cerebral vasospasm.

Neuropeptide Y ( NPY) has been demonstrated in the human circle of Willis by specific radioimmunoassay. Concentrations were similar in cadaver and peroperative specimens. NPY concentrations were highest around the basilar bifurcation (2.9 +/- 1.0 pmol/g), anterior cerebral artery (2.7 +/- 0.5 pmol/g), and carotid trifurcation (2.4 +/- 0.6 pmol/g). Concentrations were lowest in the basilar artery (1.0 +/- 0.4 pmol/g). Intracarotid administration of NPY (50 pmol to 2 nmol) to rats reduced mean cerebral cortical blood flow by 40-98%. This vasoconstriction lasted for at least 2 h. These findings suggest that NPY may be involved in the cerebral vasospasm which follows subarachnoid haemorrhage and in the maintenance of normal vascular tone.[1]

References

  1. Presence of neuropeptide Y in human circle of Willis and its possible role in cerebral vasospasm. Allen, J.M., Schon, F., Todd, N., Yeats, J.C., Crockard, H.A., Bloom, S.R. Lancet (1984) [Pubmed]
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