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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Morphological studies of the epiphyseal growth zone in the brachymorphic ( bm/ bm) mouse.

Light microscopy, including immunohistochemical techniques, and electron microscopy were performed on epiphyseal growth cartilage from brachymorphic ( bm/ bm) mice and age-matched phenotypically normal siblings aged 5, 16 and 25 days. In the bm/ bm mice light microscopy showed a disturbed columnar arrangement and numerous chondrocytes with pronounced regressive changes. The normal development of proliferative cells into hypertrophic cells was halted and thus only a rather small and ill-defined hypertrophic zone was seen. The calcifying zone was irregular and the normal lacunae were replaced by a densely staining matrix. Using immunofluorescence techniques, the presence of considerable amounts of both type II and type V collagen was demonstrated in the bm/ bm mice, while the cartilage from controls contained only type II. Ultrastructurally the lacunar matrix contained bundles of fine fibrils without the typical collagen periodicity which might indicate synthesis of a defective procollagen. Our observations together with the previously demonstrated deficiency of 3'-phosphoadenosine 5'-phosphosulphate, illustrate the complexity of the growth cartilage disturbance in the bm/ bm mouse. Most of our findings are at variance with those described in the literature and possible pathogenetic mechanisms for the observed alterations in the growth cartilage are discussed.[1]


  1. Morphological studies of the epiphyseal growth zone in the brachymorphic (bm/bm) mouse. Wikström, B., Gay, R., Gay, S., Hjerpe, A., Mengarelli, S., Reinholt, F.P., Engfeldt, B. Virchows Arch., B, Cell Pathol. (1984) [Pubmed]
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