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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Effects of tiapride on homovanillic acid levels in human cerebrospinal fluid drawn at pneumoencephalography.

The effect of tiapride on HVA and 5-HIAA levels in the CSF drawn at pneumoencephalography (PEG) was studied. Five consecutive 5 ml fractions of CSF were drawn from control and tiapride-treated subjects. In both groups, a linear increase in HVA concentrations was found between the first and subsequent fractions. On the contrary, no significant difference in 5-HIAA concentrations was found in sequential CSF samples. Tiapride increased the mean HVA concentrations and caused a steeper caudocranial gradient of this metabolite but failed to modify 5-HIAA concentrations. The results suggest that tiapride blocks dopamine (DA) receptors and increases DA synthesis.[1]

References

  1. Effects of tiapride on homovanillic acid levels in human cerebrospinal fluid drawn at pneumoencephalography. Spissu, A., Congia, S., Piccardi, M.P., Fadda, F., Mangoni, A., Gessa, G.L. Psychopharmacology (Berl.) (1980) [Pubmed]
 
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