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Chemical Compound Review

tiapride     N-(2-diethylaminoethyl)-2- methoxy-5...

Synonyms: Tiaprida, Thiapride, Tiapridal, Tiapridum, Lopac-T-0410, ...
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Disease relevance of FLO 1347


Psychiatry related information on FLO 1347


High impact information on FLO 1347


Chemical compound and disease context of FLO 1347


Biological context of FLO 1347


Anatomical context of FLO 1347


Associations of FLO 1347 with other chemical compounds


Gene context of FLO 1347

  • This study on the antinociceptive mechanism of action of tiapride (that blocks painful neuropathy in diabetic patients) has led us to hypothesize that the drug attenuates pain transmission through an indirect activation of central 5-HT1 and 5-HT2 receptors [30].
  • Five consecutive 5 ml fractions of CSF were drawn from control and tiapride-treated subjects [33].
  • Since tiapride is not available in the USA as yet, most of the studies concerning tiapride have been carried out in Europe. In a recent study, based on objective measurements, tiapride effectively controlled choreatic movements in patients suffering from Huntington's disease (HD) [17].
  • Tiapride induced an increase of prolactin plasma levels, on the average, from 1,195 to 2,179 microIU/ml (p less than 0.01) [34].
  • A patient with Huntington's disease developed acute dystonia whilst treated with tiapride [35].

Analytical, diagnostic and therapeutic context of FLO 1347

  • The patients' mental conditions significantly improved while they were taking tiapride, and did not appreciably deteriorate after treatment was discontinued [3].
  • Effects of tiapride on electroencephalograms and cognitive functions in the elderly [36].
  • This method is applicable to pharmacokinetic studies and therapeutic drug monitoring of sultopride and tiapride [31].
  • This was a retrospective study to examine the efficacy, practicability and medical safety of a combination of tiapride and unretarded (fast acting formula) carbamazepine in the treatment of alcohol withdrawal syndrome [37].
  • In a placebo-controlled double-blind crossover study of 21 patients chronically treated with neuroleptics and suffering from tardive dyskinesia, tiapride (600 mg/day, mean plasma level: 682 ng/ml) exhibited a transient efficacy during 12 weeks of treatment, most distinct in the 6th week (p less than 0.01) [34].


  1. Tiapride in Parkinson's disease. Price, P., Parkes, J.D., Marsden, C.D. Lancet (1978) [Pubmed]
  2. Tiapride-induced torsade de pointes. Iglesias, E., Esteban, E., Zabala, S., Gascon, A. Am. J. Med. (2000) [Pubmed]
  3. Tiapride in the treatment of tardive dyskinesia: a clinical and biochemical study. Perényi, A., Arató, M., Bagdy, G., Frecska, E., Szücs, R. The Journal of clinical psychiatry. (1985) [Pubmed]
  4. Tiapride. A review of its pharmacology and therapeutic potential in the management of alcohol dependence syndrome. Peters, D.H., Faulds, D. Drugs (1994) [Pubmed]
  5. Effects of tiapride in tardive dyskinesia. Pollak, P., Gaio, J.M., Hommel, M., Pellat, J., Perret, J. Psychopharmacology (Berl.) (1985) [Pubmed]
  6. Cataplexy relieved by tiapride. Paulus, W., Hömberg, V., Noth, J. Arch. Neurol. (1983) [Pubmed]
  7. Tiapride in the prevention of relapse in recently detoxified alcoholics. Shaw, G.K., Waller, S., Majumdar, S.K., Alberts, J.L., Latham, C.J., Dunn, G. The British journal of psychiatry : the journal of mental science. (1994) [Pubmed]
  8. Tiapride in 12 Huntington's disease patients. Quinn, N., Marsden, C.D. J. Neurol. Neurosurg. Psychiatr. (1985) [Pubmed]
  9. Involvement of dopaminergic neurotransmission in the control of goal-directed movements. Schmidt, W.J. Psychopharmacology (Berl.) (1983) [Pubmed]
  10. Measuring the efficacy of psychopharmacological treatment of psychomotoric restlessness in dementia: clinical evaluation of tiapride. Gutzmann, H., Kühl, K.P., Kanowski, S., Khan-Boluki, J. Pharmacopsychiatry (1997) [Pubmed]
  11. Influence of the dopamine D2 receptor (DRD2) exon 8 genotype on efficacy of tiapride and clinical outcome of alcohol withdrawal. Lucht, M.J., Kuehn, K.U., Schroeder, W., Armbruster, J., Abraham, G., Schattenberg, A., Gaensicke, M., Barnow, S., Tretzel, H., Herrmann, F.H., Freyberger, H.J. Pharmacogenetics (2001) [Pubmed]
  12. Prediction of catalepsies induced by amiodarone, aprindine and procaine: similarity in conformation of diethylaminoethyl side chain. Matsui, A., Matsuo, H., Takanaga, H., Sasaki, S., Maeda, M., Sawada, Y. J. Pharmacol. Exp. Ther. (1998) [Pubmed]
  13. Functional analysis of the D2L dopamine receptor expressed in a cAMP-responsive luciferase reporter cell line. George, S.E., Bungay, P.J., Naylor, L.H. Biochem. Pharmacol. (1998) [Pubmed]
  14. Differential regulation of D2 and D4 dopamine receptor mRNAs in the primate cerebral cortex vs. neostriatum: effects of chronic treatment with typical and atypical antipsychotic drugs. Lidow, M.S., Goldman-Rakic, P.S. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  15. Down-regulation of the D1 and D5 dopamine receptors in the primate prefrontal cortex by chronic treatment with antipsychotic drugs. Lidow, M.S., Elsworth, J.D., Goldman-Rakic, P.S. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  16. L-dopa-induced respiratory disturbance in Parkinson's disease suppressed by tiapride. De Keyser, J., Vincken, W. Neurology (1985) [Pubmed]
  17. The benzamide tiapride: treatment of extrapyramidal motor and other clinical syndromes. Dose, M., Lange, H.W. Pharmacopsychiatry (2000) [Pubmed]
  18. Tourette syndrome: efficient treatment with ziprasidone and normalization of body weight in a patient with excessive weight gain under tiapride. Meisel, A., Winter, C., Zschenderlein, R., Arnold, G. Mov. Disord. (2004) [Pubmed]
  19. Early administration of tiapride to young rats without long-lasting changes in the development of the dopaminergic system. Bock, N., Moll, G.H., Wicker, M., Pilz, J., Rüther, E., Banaschewski, T., Huether, G., Rothenberger, A. Pharmacopsychiatry (2004) [Pubmed]
  20. Comparative study of tiapride and neuroleptics with anti-dopamine activity on convulsive seizure in mice. Satoh, H., Nakanishi, H., Shirakawa, K., Kohjimoto, Y., Kuwaki, T., Ono, T., Shibayama, F. Jpn. J. Pharmacol. (1987) [Pubmed]
  21. Influence of tiapride on platelet counts in healthy volunteers and patients with movement disorders. Kotzailias, N., Finsterer, J., Aull, S., Eichler, H.G., Pratscher, B., Jilma, B. Prog. Neuropsychopharmacol. Biol. Psychiatry (2003) [Pubmed]
  22. Single oral dose pharmacokinetics of tiapride in patients with Huntington's disease. Norman, T., Chiu, E., James, R.H., Gregory, M.S. Eur. J. Clin. Pharmacol. (1987) [Pubmed]
  23. Tiapride. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in geriatric agitation. Steele, J.W., Faulds, D., Sorkin, E.M. Drugs & aging. (1993) [Pubmed]
  24. Comparison of effects of tiapride and sulpiride on D-1, D-2, D-3 and D-4 subtypes of dopamine receptors in rat striatal and bovine caudate nucleus membranes. Arima, T., Samura, N., Nomura, Y., Segawa, T. Jpn. J. Pharmacol. (1986) [Pubmed]
  25. Tiapride-induced chronic hyperprolactinaemia: interference with the human menstrual cycle. L'Hermite, M., Michaux-Duchêne, A., Robyn, C. Acta Endocrinol. (1979) [Pubmed]
  26. Benzamide action at alpha 2-adrenoceptors modifies catecholamine-induced contraction and relaxation of circular smooth muscle from guinea-pig stomach. Sahyoun, H.A., Costall, B., Naylor, R.J. Naunyn Schmiedebergs Arch. Pharmacol. (1982) [Pubmed]
  27. Effects of tiapride infusion on plasma levels of beta-endorphin, prolactin and dopamine in patients with pain from cancer. Gennari, C., Nami, R., Pizzuti, M., D'Ascenzo, G., Bianchini, C. Pathol. Biol. (1981) [Pubmed]
  28. Effect of tiapride on electroacupuncture analgesia. Dai, J.L., Xu, S.F. Zhongguo yao li xue bao = Acta pharmacologica Sinica. (1991) [Pubmed]
  29. Acute dyskinesias in monkeys elicited by halopemide, mezilamine and the "antidyskinetic" drugs, oxiperomide and tiapride. Neale, R., Fallon, S., Gerhardt, S., Liebman, J.M. Psychopharmacology (Berl.) (1981) [Pubmed]
  30. Tiapride attenuates pain transmission through an indirect activation of central serotonergic mechanism. Takeshita, N., Ohkubo, Y., Yamaguchi, I. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  31. Determination of sultopride and tiapride in serum by gas chromatography using a surface ionisation detector. Kamizono, A., Inotsume, N., Miyamoto, K., Ueda, K., Miyakawa, T., Arimoto, H., Nakano, M. J. Chromatogr. (1991) [Pubmed]
  32. Treatment of alcohol withdrawal: tiapride and carbamazepine versus clomethiazole. A pilot study. Franz, M., Dlabal, H., Kunz, S., Ulferts, J., Gruppe, H., Gallhofer, B. European archives of psychiatry and clinical neuroscience. (2001) [Pubmed]
  33. Effects of tiapride on homovanillic acid levels in human cerebrospinal fluid drawn at pneumoencephalography. Spissu, A., Congia, S., Piccardi, M.P., Fadda, F., Mangoni, A., Gessa, G.L. Psychopharmacology (Berl.) (1980) [Pubmed]
  34. Tiapride: effects on tardive dyskinesia and on prolactin plasma concentrations. Greil, W., Auberger, S., Haag, H., Rüther, E. Neuropsychobiology (1985) [Pubmed]
  35. Neuroleptically induced dystonia in Huntington's disease: a case report. Schott, K., Ried, S., Stevens, I., Dichgans, J. Eur. Neurol. (1989) [Pubmed]
  36. Effects of tiapride on electroencephalograms and cognitive functions in the elderly. Patat, A., Alberini, H., Bonhomme, D., Soubrane, C., Allain, H., Gandon, J.M. International clinical psychopharmacology. (1999) [Pubmed]
  37. Treatment of alcohol withdrawal syndrome with a combination of tiapride/carbamazepine : Results of a pooled analysis in 540 patients. Soyka, M., Schmidt, P., Franz, M., Barth, T., de Groot, M., Kienast, T., Reinert, T., Richter, C., Sander, G. European archives of psychiatry and clinical neuroscience. (2006) [Pubmed]
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