The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Homovanillic acid     2-(4-hydroxy-3-methoxy- phenyl)ethanoic acid

Synonyms: Homovanilate, Vanilacetate, Homovanillate, Lopac-H-1252, CHEMBL1562, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Homovanillic acid


Psychiatry related information on Homovanillic acid


High impact information on Homovanillic acid


Chemical compound and disease context of Homovanillic acid


Biological context of Homovanillic acid


Anatomical context of Homovanillic acid


Associations of Homovanillic acid with other chemical compounds


Gene context of Homovanillic acid

  • Behavior was assessed and blood samples analyzed for growth hormone (GH), prolactin (PRL), homovanillic acid (HVA), and amphetamine [36].
  • In the right putamen, GDNF infusion produced a 217% increase in homovanillic acid (HVA) levels [37].
  • HIAA vs HVA as well as CRF vs END correlated strongly in the total and both subgroups [38].
  • The method is based on the peroxidase-mediated oxidation of homovanillic acid (HVA) under appropriate assay conditions in which EPO is still very active in catalyzing the reaction whilst MPO-mediated HVA oxidation is almost undetectable [39].
  • CONCLUSION: The elevation of DOPAC and the decrease of HVA and HVA / DOPAC reflect a shift of the levodopa metabolism towards the MAO-B dependent oxidative pathway [40].

Analytical, diagnostic and therapeutic context of Homovanillic acid


  1. Treatment and prognosis of hemiballismus. Klawans, H.L., Moses, H., Nausieda, P.A., Bergen, D., Weiner, W.J. N. Engl. J. Med. (1976) [Pubmed]
  2. The clinical syndrome of striatal dopamine deficiency. Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Burns, R.S., LeWitt, P.A., Ebert, M.H., Pakkenberg, H., Kopin, I.J. N. Engl. J. Med. (1985) [Pubmed]
  3. Lead poisoning: altered urinary catecholamine metabolites as indicators of intoxication in mice and children. Silbergeld, E.K., Chisolm, J.J. Science (1976) [Pubmed]
  4. Urinary excretion of 3-methoxy-4-hydroxymandelic acid and 3-methoxy-4-hydroxyphenylacetic acid by 288 patients with neuroblastoma and related neural crest tumors. LaBrosse, E.H., Com-Nougué, C., Zucker, J.M., Comoy, E., Bohuon, C., Lemerle, J., Schweisguth, O. Cancer Res. (1980) [Pubmed]
  5. Effects of hypoxia-ischemia on monoamine metabolism in the immature brain. Silverstein, F., Johnston, M.V. Ann. Neurol. (1984) [Pubmed]
  6. Mental symptoms in Huntington's disease and a possible primary aminergic neuron lesion. Mann, J.J., Stanley, M., Gershon, S., Rossor, M. Science (1980) [Pubmed]
  7. Plasma homovanillic acid levels in first-episode schizophrenia. Psychopathology and treatment response. Koreen, A.R., Lieberman, J., Alvir, J., Mayerhoff, D., Loebel, A., Chakos, M., Amin, F., Cooper, T. Arch. Gen. Psychiatry (1994) [Pubmed]
  8. Cerebrospinal fluid and plasma monoamine metabolites and their relation to psychosis. Implications for regional brain dysfunction in schizophrenia. Pickar, D., Breier, A., Hsiao, J.K., Doran, A.R., Wolkowitz, O.M., Pato, C.N., Konicki, P.E., Potter, W.Z. Arch. Gen. Psychiatry (1990) [Pubmed]
  9. Alzheimer's disease and its Lewy body variant: a clinical analysis of postmortem verified cases. Weiner, M.F., Risser, R.C., Cullum, C.M., Honig, L., White, C., Speciale, S., Rosenberg, R.N. The American journal of psychiatry. (1996) [Pubmed]
  10. Low CSF concentration of a dopamine metabolite in tobacco smokers. Geracioti, T.D., West, S.A., Baker, D.G., Hill, K.K., Ekhator, N.N., Wortman, M.D., Keck, P.E., Norman, A.B. The American journal of psychiatry. (1999) [Pubmed]
  11. Sex differences in plasma homovanillic acid in acute psychosis. Bowers, M.B., Swigar, M.E., Jatlow, P.I. N. Engl. J. Med. (1983) [Pubmed]
  12. Effect of baclofen on cerebrospinal-fluid levels of 5-hydroxyindoleacetic acid and homovanillic acid. Walinder, J., Wallin, L., Carlsson, A. N. Engl. J. Med. (1977) [Pubmed]
  13. Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors. Heikkila, R.E., Manzino, L., Cabbat, F.S., Duvoisin, R.C. Nature (1984) [Pubmed]
  14. Dopamine-beta-hydroxylase activity and homovanillic acid in spinal fluid of schizophrenics with brain atrophy. van Kammen, D.P., Mann, L.S., Sternberg, D.E., Scheinin, M., Ninan, P.T., Marder, S.R., van Kammen, W.B., Rieder, R.O., Linnoila, M. Science (1983) [Pubmed]
  15. Antipsychotic drug action in schizophrenic patients: effect on cortical dopamine metabolism after long-term treatment. Bacopoulos, N.C., Spokes, E.G., Bird, E.D., Roth, R.H. Science (1979) [Pubmed]
  16. Neurochemistry of dopamine in Huntington's dementia and normal aging. Stahl, S.M., Thiemann, S., Faull, K.F., Barchas, J.D., Berger, P.A. Arch. Gen. Psychiatry (1986) [Pubmed]
  17. Monoamine neurotransmitter interactions in drug-free and neuroleptic-treated schizophrenics. Hsiao, J.K., Colison, J., Bartko, J.J., Doran, A.R., Konicki, P.E., Potter, W.Z., Pickar, D. Arch. Gen. Psychiatry (1993) [Pubmed]
  18. Cerebrospinal fluid neurochemistry in the myoclonic subtype of Alzheimer's disease. Kaye, J.A., May, C., Atack, J.R., Daly, E., Sweeney, D.L., Beal, M.F., Kaufman, S., Milstien, S., Friedland, R.P., Rapoport, S.I. Ann. Neurol. (1988) [Pubmed]
  19. Characteristics of patients with the highest plasma catecholamine metabolite levels. Bowers, M.B., Swigar, M.E., Hoffman, F.J., Goicoechea, N. The American journal of psychiatry. (1988) [Pubmed]
  20. Dopamine transmission in DYT1 dystonia: a biochemical and autoradiographical study. Augood, S.J., Hollingsworth, Z., Albers, D.S., Yang, L., Leung, J.C., Muller, B., Klein, C., Breakefield, X.O., Standaert, D.G. Neurology (2002) [Pubmed]
  21. Modulation of activity of the striatal dopaminergic system during the hibernation cycle. Kilduff, T.S., Bowersox, S.S., Faull, K.F., Zeller-DeAmicis, L., Radeke, C.M., Ciaranello, R.D., Heller, H.C., Barchas, J.D., Dement, W.C. J. Neurosci. (1987) [Pubmed]
  22. Vitamin B6, magnesium, and combined B6-Mg: therapeutic effects in childhood autism. Martineau, J., Barthelemy, C., Garreau, B., Lelord, G. Biol. Psychiatry (1985) [Pubmed]
  23. Molecular detection of GAGE expression in peripheral blood and bone marrow: utility as a tumor marker for neuroblastoma. Cheung, I.Y., Cheung, N.K. Clin. Cancer Res. (1997) [Pubmed]
  24. Genetics of monoamine metabolites in baboons: overlapping sets of genes influence levels of 5-hydroxyindolacetic acid, 3-hydroxy-4-methoxyphenylglycol, and homovanillic acid. Rogers, J., Martin, L.J., Comuzzie, A.G., Mann, J.J., Manuck, S.B., Leland, M., Kaplan, J.R. Biol. Psychiatry (2004) [Pubmed]
  25. Cerebrospinal fluid levels of monoamine metabolites. A preliminary study of their relation to menstrual cycle phase, sex steroids, and pituitary hormones in healthy women and in women with premenstrual syndrome. Eriksson, E., Alling, C., Andersch, B., Andersson, K., Berggren, U. Neuropsychopharmacology (1994) [Pubmed]
  26. Effects of metabolic perturbation on plasma homovanillic acid in schizophrenia. Relationship to prefrontal cortex volume. Breier, A., Davis, O.R., Buchanan, R.W., Moricle, L.A., Munson, R.C. Arch. Gen. Psychiatry (1993) [Pubmed]
  27. An animal model of early-treated PKU. Diamond, A., Ciaramitaro, V., Donner, E., Djali, S., Robinson, M.B. J. Neurosci. (1994) [Pubmed]
  28. Rapid-onset dystonia-parkinsonism: linkage to chromosome 19q13. Kramer, P.L., Mineta, M., Klein, C., Schilling, K., de Leon, D., Farlow, M.R., Breakefield, X.O., Bressman, S.B., Dobyns, W.B., Ozelius, L.J., Brashear, A. Ann. Neurol. (1999) [Pubmed]
  29. Locus ceruleus lesion by local 6-hydroxydopamine infusion causes marked and specific destruction of noradrenergic neurons, long-term depletion of norepinephrine and the enzymes that synthesize it, and enhanced dopaminergic mechanisms in the ipsilateral cerebral cortex. Harik, S.I. J. Neurosci. (1984) [Pubmed]
  30. Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distribution. Piggott, M.A., Marshall, E.F., Thomas, N., Lloyd, S., Court, J.A., Jaros, E., Burn, D., Johnson, M., Perry, R.H., McKeith, I.G., Ballard, C., Perry, E.K. Brain (1999) [Pubmed]
  31. Stimulation of dopamine synthesis in caudate nucleus by intrastriatal enkephalins and antagonism by naloxone. Biggio, G., Casu, M., Corda, M.G., Di Bello, C., Gessa, G.L. Science (1978) [Pubmed]
  32. Bupropion in depression. I. Biochemical effects and clinical response. Golden, R.N., Rudorfer, M.V., Sherer, M.A., Linnoila, M., Potter, W.Z. Arch. Gen. Psychiatry (1988) [Pubmed]
  33. Effects of a dopamine agonist piribedil in depressed patients: relationship of pretreatment homovanillic acid to antidepressant response. Post, R.M., Gerner, R.H., Carman, J.S., Gillin, J.C., Jimerson, D.C., Goodwin, F.K., Bunney, W.E. Arch. Gen. Psychiatry (1978) [Pubmed]
  34. High doses of haloperidol in schizophrenia. A clinical, biochemical, and pharmacokinetic study. Zarifian, E., Scatton, B., Bianchetti, G., Cuche, H., Loo, H., Morselli, P.L. Arch. Gen. Psychiatry (1982) [Pubmed]
  35. Clinical and biologic response to clozapine in patients with schizophrenia. Crossover comparison with fluphenazine. Pickar, D., Owen, R.R., Litman, R.E., Konicki, E., Gutierrez, R., Rapaport, M.H. Arch. Gen. Psychiatry (1992) [Pubmed]
  36. The neuroendocrine and behavioral response to dextroamphetamine in normal individuals. Dommisse, C.S., Schulz, S.C., Narasimhachari, N., Blackard, W.G., Hamer, R.M. Biol. Psychiatry (1984) [Pubmed]
  37. Effects of chronic intraputamenal infusion of glial cell line-derived neurotrophic factor (GDNF) in aged Rhesus monkeys. Maswood, N., Grondin, R., Zhang, Z., Stanford, J.A., Surgener, S.P., Gash, D.M., Gerhardt, G.A. Neurobiol. Aging (2002) [Pubmed]
  38. The concentrations of monoamine metabolites and neuropeptides in the cerebrospinal fluid of obese women with different body fat distribution. Strömbom, U., Krotkiewski, M., Blennow, K., Månsson, J.E., Ekman, R., Björntorp, P. Int. J. Obes. Relat. Metab. Disord. (1996) [Pubmed]
  39. Oxidation of homovanillic acid as a selective assay for eosinophil peroxidase in eosinophil peroxidase-myeloperoxidase mixtures and its use in the detection of human eosinophil peroxidase deficiency. Menegazzi, R., Zabucchi, G., Zuccato, P., Cramer, R., Piccinini, C., Patriarca, P. J. Immunol. Methods (1991) [Pubmed]
  40. COMT-inhibition increases serum levels of dihydroxyphenylacetic acid (DOPAC) in patients with advanced Parkinson's disease. Oechsner, M., Buhmann, C., Strauss, J., Stuerenburg, H.J. Journal of neural transmission (Vienna, Austria : 1996) (2002) [Pubmed]
  41. Plasma homovanillic acid concentration and the severity of schizophrenic illness. Davis, K.L., Davidson, M., Mohs, R.C., Kendler, K.S., Davis, B.M., Johns, C.A., DeNigris, Y., Horvath, T.B. Science (1985) [Pubmed]
  42. Monoamine metabolites in CSF and suicidal behavior. Träskman, L., Asberg, M., Bertilsson, L., Sjöstrand, L. Arch. Gen. Psychiatry (1981) [Pubmed]
  43. Dopamine release and metabolism in awake rats after systemic neuroleptics as studied by trans-striatal dialysis. Imperato, A., Di Chiara, G. J. Neurosci. (1985) [Pubmed]
  44. The transfer of rats from a familiar to a novel environment prolongs the increase of extracellular dopamine efflux induced by CCK8 in the posterior nucleus accumbens. Ladurelle, N., Roques, B.P., Daugé, V. J. Neurosci. (1995) [Pubmed]
WikiGenes - Universities