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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Hydantoin drugs inhibit polymerization of pure microtubular protein.

5,5-Diphenylhydantoin or 5-(4-hydroxyphenyl)-5-phenylhydantoin, 3.6 X 10(-4) M, inhibited polymerization of purified pig brain tubulin 50% as measured by viscosometric assay and estimation of tubulin length by electron microscopy. 5,5-Diphenylhydantoin did not bind to the low molecular weight fraction of tubulin or to guanosinetriphosphate; it displaced colchicine weakly from its binding site. 5,5-Diphenylhydantoin did not depolymerize established microtubules, indicating that it differs from colchicine in site and mode of action.[1]

References

  1. Hydantoin drugs inhibit polymerization of pure microtubular protein. MacKinney, A.A., Vyas, R.S., Walker, D. J. Pharmacol. Exp. Ther. (1978) [Pubmed]
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