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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Potentiation of bleomycin lethality by anticalmodulin drugs: a role for calmodulin in DNA repair.

Treatment of exponentially growing Chinese hamster ovary cells with bleomycin causes a dose-dependent decrease in cell survival due to DNA damage. This lethal effect can be potentiated by the addition of a nonlethal dose of the anticalmodulin drug N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide ( W13 ) but not its inactive analog N-(4-aminobutyl)-2-naphthalenesulfonamide ( W12 ). By preventing the repair of damaged DNA, W13 also inhibits recovery from potentially lethal damage induced by bleomycin. These data suggest a role for calmodulin in the DNA repair pathway.[1]

References

  1. Potentiation of bleomycin lethality by anticalmodulin drugs: a role for calmodulin in DNA repair. Chafouleas, J.G., Bolton, W.E., Means, A.R. Science (1984) [Pubmed]
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