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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine.

Vancomycin, a broad-spectrum antibiotic, inhibits the growth of cell walls by complex formation with peptides terminating in D-alanyl-D-alanine. The structure of vancomycin was determined by X-ray analysis of the degradation product CDP-I. A model of the complex is proposed based on this study and spectroscopic data.[1]


  1. Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanine. Sheldrick, G.M., Jones, P.G., Kennard, O., Williams, D.H., Smith, G.A. Nature (1978) [Pubmed]
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