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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Chlorozotocin treatment of advanced gastrointestinal cancer.

From April 1981 to December 1981, 34 consecutive patients with advanced gastrointestinal cancer were treated with chlorozotocin at the dosage of 40 mg/m2 daily for 5 consecutive days (30 mg/m2 in patients pretreated with chemotherapy) every 6 weeks. In the 30 patients evaluable for response, a 3.3% objective response rate was encountered. Toxicity was not significant and consisted mainly in reversible myelosuppression. Median survival was 3 months. At the dosage and schedule used, chlorozotocin does not seem to be an effective agent in the treatment of advanced gastrointestinal cancer.[1]


  1. Chlorozotocin treatment of advanced gastrointestinal cancer. Veronesi, A., Magri, M.D., Tirelli, U., Galligioni, E., Figoli, F., Zagonel, V., Tumolo, S., Grigoletto, E. Med. Pediatr. Oncol. (1983) [Pubmed]
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