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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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DNA synthesis in cartilage cells is stimulated by oscillating electric fields.

External oscillating electric fields (1166 volts per centimeter, 5 hertz) enhanced the incorporation of [3H] thymidine into the DNA of chondrocytes isolated from the proliferative layer of embryonic (16 days) chick epiphysis. Verapamil or tetrodotoxin at 10(-6)M concentrations completely blocked the electric field effect. Tetracaine reduced the incorporation of [3H] thymidine in both control and electrically stimulated cells. The findings support the hypothesis that Na and Ca2 fluxes generated by the electrical perturbation trigger DNA synthesis in these cells.[1]

References

  1. DNA synthesis in cartilage cells is stimulated by oscillating electric fields. Rodan, G.A., Bourret, L.A., Norton, L.A. Science (1978) [Pubmed]
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