Phosphoglycolate phosphatase and 2,3-diphosphoglycerate in red cells of normal and anemic subjects.
Red cell phosphoglycolate phosphatase ( PGP) and 2,3-diphosphoglycerate (2,3-DPG) were investigated in normal and anemic patients and rabbits. In hemolytic anemia and blood-loss anemia, characterized by a young red cell population, there was an increase in both phosphoglycolate phosphatase activity and 2,3-diphosphoglycerate levels. In aplastic anemia, the phosphoglycolate phosphatase activity was normal, but the 2,3-diphosphoglycerate values were nonetheless increased. Thus, no relationship was found between phosphoglycolate phosphatase activity and 2,3-diphosphoglycerate levels. The lack of correlation between the activity of phosphoglycolate phosphatase and 2,3-DPG levels suggests that modulation of phosphoglycolate phosphatase activity does not control the level of 2,3-DPG in erythrocytes.[1]References
- Phosphoglycolate phosphatase and 2,3-diphosphoglycerate in red cells of normal and anemic subjects. Somoza, R., Beutler, E. Blood (1983) [Pubmed]
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