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Chemical Compound Review

2,3-Dpg     2,3-diphosphonooxypropanoic acid

Synonyms: CHEMBL144103, AG-D-78390, CHEBI:28907, CTK4C1410, AR-1D2305, ...
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Disease relevance of 2,3-Bisphosphoglycerate


Psychiatry related information on 2,3-Bisphosphoglycerate


High impact information on 2,3-Bisphosphoglycerate


Chemical compound and disease context of 2,3-Bisphosphoglycerate


Biological context of 2,3-Bisphosphoglycerate

  • Although a decrease in the positive charge density at the binding sites of 2,3-diphosphoglycerate in hemoglobin Rahere apparently shifts the allosteric equilibrium toward the low affinity state, it greatly diminishes the cofactor effects by anions [17].
  • We conclude that the nonenzymatic glycosylation of hemoglobin is influenced by factors other than glucose, including oxygen tension and 2,3-diphosphoglycerate levels [18].
  • From osmotic fragility, plasma trapping, erythrocyte ATP and 2,3-diphosphoglycerate (DPG), and serum phosphorus, calcium, and magnesium measurements it seems unlikely that either spheric transformation or sol-gel transformation of the membrane is causing the increased erythrocyte rigidity [19].
  • Sherpas living permanently at 4000 m above sea level do not have increased hematological parameters (i.e., red cell number, hematocrit, hemoglobin content, and 2,3-diphosphoglycerate/hemoglobin ratio) and have a higher affinity of blood for oxygen as compared with acclimatized Caucasians [20].
  • In such cells the PGK step presumably was inoperative due to total lack of substrate; 2,3-diphosphoglycerate (2,3-DPG) then became the sole substrate source for remaining steps in glycolysis [21].

Anatomical context of 2,3-Bisphosphoglycerate


Associations of 2,3-Bisphosphoglycerate with other chemical compounds


Gene context of 2,3-Bisphosphoglycerate


Analytical, diagnostic and therapeutic context of 2,3-Bisphosphoglycerate


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  2. Structure and mechanism of action of a novel phosphoglycerate mutase from Bacillus stearothermophilus. Jedrzejas, M.J., Chander, M., Setlow, P., Krishnasamy, G. EMBO J. (2000) [Pubmed]
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  6. 31P NMR relaxation time studies of 2,3-diphosphoglycerate in solution and intact erythrocytes. Christensen, M., Jacobsen, J.P. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (1988) [Pubmed]
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  16. Determination of glucose metabolites in stored erythrocytes and in erythrocytes from patients with thalassemia by analytical isotachophoresis. Ku??i, Z., Hins, J., Ku??i, S., Renner, S., Flottmann, D., Bruchelt, G. J. Biochem. Biophys. Methods (2006) [Pubmed]
  17. Hemoglobin Rahere, a human hemoglobin variant with amino acid substitution at the 2,3-diphosphoglycerate binding site. Functional consequences of the alteration and effects of bezafibrate on the oxygen bindings. Sugihara, J., Imamura, T., Nagafuchi, S., Bonaventura, J., Bonaventura, C., Cashon, R. J. Clin. Invest. (1985) [Pubmed]
  18. Regulation of hemoglobin AIc formation in human erythrocytes in vitro. Effects of physiologic factors other than glucose. Smith, R.J., Koenig, R.J., Binnerts, A., Soeldner, J.S., Aoki, T.T. J. Clin. Invest. (1982) [Pubmed]
  19. Oxidative injury to erythrocytes, cell rigidity, and splenic hemolysis in hemodialyzed uremic patients. Rosenmund, A., Binswanger, U., Straub, P.W. Ann. Intern. Med. (1975) [Pubmed]
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  21. Energy metabolism in human erythrocytes: the role of phosphoglycerate kinase in cation transport. Segel, G.B., Feig, S.A., Glader, B.E., Muller, A., Dutcher, P., Nathan, D.G. Blood (1975) [Pubmed]
  22. Myocardial function and hemoglobin oxygen affinity during hyperglycemia in the fetal lamb. Bard, H., Fouron, J.C., De Muylder, X., Ducharme, G., Lafond, J.S. J. Clin. Invest. (1986) [Pubmed]
  23. Erythrocyte membrane deformability and stability: two distinct membrane properties that are independently regulated by skeletal protein associations. Chasis, J.A., Mohandas, N. J. Cell Biol. (1986) [Pubmed]
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  30. Molecular cloning and sequencing of the human erythrocyte 2,3-bisphosphoglycerate mutase cDNA: revised amino acid sequence. Joulin, V., Peduzzi, J., Roméo, P.H., Rosa, R., Valentin, C., Dubart, A., Lapeyre, B., Blouquit, Y., Garel, M.C., Goossens, M. EMBO J. (1986) [Pubmed]
  31. Cloning and sequencing of a cDNA encoding 2,3-bisphosphoglycerate-independent phosphoglycerate mutase from maize. Possible relationship to the alkaline phosphatase family. Graña, X., de Lecea, L., el-Maghrabi, M.R., Ureña, J.M., Caellas, C., Carreras, J., Puigdomenech, P., Pilkis, S.J., Climent, F. J. Biol. Chem. (1992) [Pubmed]
  32. Isolation and properties of the glycolytic enzymes from Zymomonas mobilis. The five enzymes from glyceraldehyde-3-phosphate dehydrogenase through to pyruvate kinase. Pawluk, A., Scopes, R.K., Griffiths-Smith, K. Biochem. J. (1986) [Pubmed]
  33. Phosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase and enolase activity and isoenzymes in lung, colon and liver carcinomas. Durany, N., Joseph, J., Campo, E., Molina, R., Carreras, J. Br. J. Cancer (1997) [Pubmed]
  34. Cloning, purification, crystallization and preliminary crystallographic analysis of human phosphoglycerate mutase. Wang, Y., Cheng, Z., Liu, L., Wei, Z., Wan, M., Gong, W. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
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  36. Synthesis and evaluation of a prototypal artificial red cell. Hunt, C.A., Burnette, R.R., MacGregor, R.D., Strubbe, A.E., Lau, D.T., Taylor, N., Kiwada, H. Science (1985) [Pubmed]
  37. Human red cell 2,3-diphosphoglycerate mutase and monophosphoglycerate mutase: genetic evidence for two separate loci. Chen, S.H., Anderson, J.E., Giblett, E.R. Am. J. Hum. Genet. (1977) [Pubmed]
  38. Recombinant human sickle hemoglobin expressed in yeast. Martin de Llano, J.J., Schneewind, O., Stetler, G., Manning, J.M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
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