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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A polypeptide containing 55 amino acid residues coded by the pre-S region of hepatitis B virus deoxyribonucleic acid bears the receptor for polymerized human as well as chimpanzee albumins.

The receptor for polymerized human and chimpanzee albumins has been identified on a hepatitis B surface antigen polypeptide of approximately 31,000 daltons. The polypeptide, designated P31, is composed of the major polypeptide of hepatitis B surface antigen ( P22) and an additional, as yet unidentified, amino acid sequence. We split P31 with cyanogen bromide and obtained a polypeptide of approximately 8000 daltons (P8) that contained carbohydrate. P8 could bind to polymerized human and chimpanzee albumins, but not to polymerized albumins from animals without susceptibility to hepatitis B virus. The amino acid composition of P8 closely resembled that of 55 amino-acid sequence coded by the pre-S region in the deoxyribonucleic acid of hepatitis B virus. Using monoclonal antibody against P8, a solid-phase sandwich radioimmunoassay was developed for the specific determination of hepatitis B surface antigen bearing the receptor for polymerized albumin in the serum of patients with hepatitis B virus infection.[1]

References

  1. A polypeptide containing 55 amino acid residues coded by the pre-S region of hepatitis B virus deoxyribonucleic acid bears the receptor for polymerized human as well as chimpanzee albumins. Machida, A., Kishimoto, S., Ohnuma, H., Baba, K., Ito, Y., Miyamoto, H., Funatsu, G., Oda, K., Usuda, S., Togami, S. Gastroenterology (1984) [Pubmed]
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