- Treatment of first episodes of genital herpes simplex virus infection with oral acyclovir. A randomized double-blind controlled trial in normal subjects. Bryson, Y.J., Dillon, M., Lovett, M., Acuna, G., Taylor, S., Cherry, J.D., Johnson, B.L., Wiesmeier, E., Growdon, W., Creagh-Kirk, T., Keeney, R. N. Engl. J. Med. (1983)