The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Induction of oxygen-dependent lethal damage by monochromatic UVB (313 nm) radiation: strand breakage, repair and cell death.

The action of 313 nm radiation in cellular inactivation (biological measurements) and induction and repair of DNA strand breaks (physical measurements) were studied in a repair proficient strain and three repair deficient strains (polA, recA, uvrA) of Escherichia coli K-12. Although the induction of breaks was linear in purified T4DNA (6.3 X 10(-4) breaks/2.5 X 10(9) daltons/Jm-2) and the polA strain (4 X 10(-4) breaks/2.5 X 10(9) daltons/Jm-2), simultaneous induction and repair of breaks were observed in the uvrA, recA and repair proficient strains at doses less than 5 X 10(4) Jm-2. The final rates of induction in these strains were 1 X 10(-4), 7.5 X 10(-5) and 7.5 X 10(-5) breaks/2.5 X 10(9) daltons/Jm-2, respectively. A highly efficient polA-dependent repair occurring at 0 degree C in minimal buffer and a second slower type of repair occurring at 31 degrees C in the polA strain were detected. Oxygen dependence of cellular inactivation was observed for the polA and repair proficient strains irradiated at 313 nm thus providing biological evidence for an oxygen-dependent lesion involved in lethality in the short wavelength range of the solar u.v. The lower hypoxic break induction rates of the polA (1.6 X 10(-4) breaks/2.5 X 10(9) daltons/Jm-2) and the repair proficient (3.6 X 10(-5) breaks/2.5 X 10(9) daltons/Jm-2) strains, indicate oxygen-enhanced DNA breakage by 313 nm radiation.[1]


WikiGenes - Universities