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Gene Review

uvrA  -  ATPase and DNA damage recognition protein...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4050, JW4019, dar
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Disease relevance of uvrA


High impact information on uvrA


Chemical compound and disease context of uvrA


Biological context of uvrA


Anatomical context of uvrA


Associations of uvrA with chemical compounds


Regulatory relationships of uvrA

  • The transcriptional regulation of the ssb and uvrA genes from P. mirabilis and S. marcescens in SOS-induced E. coli cells was studied using lacZ fusions [21].
  • We reported earlier that the SOS box of the neighbouring uvrA gene also controls the transcription of the ssb gene [22].
  • These results establish that uvrA is repressed by lexA in vivo whereas ssbA is not [23].

Other interactions of uvrA

  • The cloned uvrA and uvrB genes were placed under control of the E. coli bacteriophage lambda PL promoter for amplification of expression [24].
  • We have cloned the soxR locus, which is positioned near the uvrA gene at 92.2 min on the genetic map, by monitoring complementation of a delta soxR mutation [25].
  • Introduction of the delta polA mutation into uvrA recF cells made them deficient in the repair of DNA double-strand breaks after UV irradiation [26].
  • The lack of derepression of recA, uvrA and alkA indicated that damage to the DNA was not induced in the E. coli strains tested [27].
  • Unlike in E. coli, the expression levels of the nucleotide excision repair (NER) component genes uvrA, uvrB, and uvrD were not damage inducible in MR-1 [2].

Analytical, diagnostic and therapeutic context of uvrA

  • Expression of the denV gene product, endonuclease V, was confirmed in DNA repair-deficient Escherichia coli (uvrA recA) by Western blot analyses and by enhancements of resistance to UV irradiation [28].
  • Mutagenic potential of static magnetic fields up to 5T (T:1T=10,000 G) was not detected by the bacterial mutagenicity test using four strains of Salmonella typhimurium (TA98, TA100, TA1535 and TA1537) and Escherichia coli WP2 uvrA either in the pre-incubation method or in the plate incorporation method [29].


  1. Repair of haloethylnitrosourea-induced DNA damage in mutant and adapted bacteria. Kacinski, B.M., Rupp, W.D., Ludlum, D.B. Cancer Res. (1985) [Pubmed]
  2. Survival of Shewanella oneidensis MR-1 after UV radiation exposure. Qiu, X., Sundin, G.W., Chai, B., Tiedje, J.M. Appl. Environ. Microbiol. (2004) [Pubmed]
  3. Cloning and genetic analysis of the UV resistance determinant (uvr) encoded on the Enterococcus faecalis pheromone-responsive conjugative plasmid pAD1. Ozawa, Y., Tanimoto, K., Fujimoto, S., Tomita, H., Ike, Y. J. Bacteriol. (1997) [Pubmed]
  4. The action of 4-hydroxyaminobiphenyl in Escherichia coli: cytotoxic and mutagenic effects in DNA repair deficient strains. Suzuki, M., Takahashi, K., Morita, T., Kojima, M., Tada, M. Mutat. Res. (1993) [Pubmed]
  5. uvrA and recA mutations inhibit a site-specific transition produced by a single O6-methylguanine in gene G of bacteriophage phi X174. Chambers, R.W., Sledziewska-Gojska, E., Hirani-Hojatti, S., Borowy-Borowski, H. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  6. Phosphotransferase-mediated regulation of carbohydrate utilisation in Escherichia coli K12: identification of the products of genes on the specialised transducing phages lambda iex (crr) and lambda gsr (tgs). Britton, P., Murfitt, D., Parra, F., Jones-Mortimer, M.C., Kornberg, H.L. EMBO J. (1982) [Pubmed]
  7. Multiple pathways for SOS-induced mutagenesis in Escherichia coli: an overexpression of dinB/dinP results in strongly enhancing mutagenesis in the absence of any exogenous treatment to damage DNA. Kim, S.R., Maenhaut-Michel, G., Yamada, M., Yamamoto, Y., Matsui, K., Sofuni, T., Nohmi, T., Ohmori, H. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  8. Differences in DNA damage induced by mutagenic and nonmutagenic 4-aminoazobenzene derivatives in Escherichia coli. Kojima, M., Morita, T., Degawa, M., Hashimoto, Y., Tada, M. Mutat. Res. (1992) [Pubmed]
  9. Aflatoxin B1 activation to a plasmid mutagen by a chemical model of cytochrome P-450. Wood, M.L., Smith, J.R., Garner, R.C. Mutat. Res. (1987) [Pubmed]
  10. Mechanisms of the radioprotective effect of cysteamine in Escherichia coli. Korystov YuN, n.u.l.l., Vexler, F.B. Radiat. Res. (1988) [Pubmed]
  11. Identification of the uvrA6 mutation of Escherichia coli. Brandsma, J.A., de Ruijter, M., Brouwer, J., van de Putte, P. J. Bacteriol. (1988) [Pubmed]
  12. Enhancement of the uvrA gene dosage reduces pyrimidine dimer excision in UV-irradiated Escherichia coli. Betina, S., Masek, F., Kleibl, K. Mutat. Res. (1993) [Pubmed]
  13. Sequence-dependent interactions of two forms of UvrC with DNA helix-stabilizing CC-1065-N3-adenine adducts. Nazimiec, M., Lee, C.S., Tang, Y.L., Ye, X., Case, R., Tang, M. Biochemistry (2001) [Pubmed]
  14. Further characterization of repair of 8-methoxypsoralen crosslinks in UV-excision-defective Escherichia coli. Bridges, B.A. Mutat. Res. (1984) [Pubmed]
  15. Isolation of Brucella abortus ssb and uvrA genes from a genomic library by use of lymphocytes as probes. Zhu, Y., Oliveira, S.C., Splitter, G.A. Infect. Immun. (1993) [Pubmed]
  16. Further characterization of an E. coli strain resistant to the toxic and mutagenic action of cis-diamminedichloroplatinum(II). Villani, G., Lherisson, C., Defais, M., Johnson, N.P. Mutat. Res. (1987) [Pubmed]
  17. An ovulation inducing agent containing clomiphene citrate causes DNA-strand breaks without SOS responses in Escherichia coli. Ohnishi, T., Ohashi, Y., Amano, I., Nozu, K. Mutat. Res. (1986) [Pubmed]
  18. The expression of Escherichia coli SOS genes recA and uvrA is inducible by polyamines. Oh, T.J., Kim, I.G. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  19. Ascorbate enhances u.v.-mutagenesis in E. coli but inhibits it in Chinese hamster cells. Rossman, T.G., Klein, C.B., Naslund, M. Carcinogenesis (1986) [Pubmed]
  20. Role of DNA replication and repair in thymineless death in Escherichia coli. Morganroth, P.A., Hanawalt, P.C. J. Bacteriol. (2006) [Pubmed]
  21. The single-stranded-DNA-binding proteins (SSB) of Proteus mirabilis and Serratia marcescens. De Vries, J., Genschel, J., Urbanke, C., Thole, H., Wackernagel, W. Eur. J. Biochem. (1994) [Pubmed]
  22. Analysis of the regulatory region of the ssb gene of Escherichia coli. Brandsma, J.A., Bosch, D., de Ruÿter, M., van de Putte, P. Nucleic Acids Res. (1985) [Pubmed]
  23. Study of the expression of UVRA and SSB proteins in vivo in lambda hybrid phages containing the uvrA and ssbA genes of Escherichia coli. Alazard, R.J. Mutat. Res. (1983) [Pubmed]
  24. The purification of the Escherichia coli UvrABC incision system. Yeung, A.T., Mattes, W.B., Oh, E.Y., Yoakum, G.H., Grossman, L. Nucleic Acids Res. (1986) [Pubmed]
  25. Molecular characterization of the soxRS genes of Escherichia coli: two genes control a superoxide stress regulon. Amábile-Cuevas, C.F., Demple, B. Nucleic Acids Res. (1991) [Pubmed]
  26. Role of DNA polymerase I in postreplication repair: a reexamination with Escherichia coli delta polA. Sharma, R.C., Smith, K.C. J. Bacteriol. (1987) [Pubmed]
  27. Rice seedling whole exudates and extracted alkylresorcinols induce stress-response in Escherichia coli biosensors. Miché, L., Belkin, S., Rozen, R., Balandreau, J. Environ. Microbiol. (2003) [Pubmed]
  28. Expression of the bacteriophage T4 denV structural gene in Escherichia coli. Recinos, A., Augustine, M.L., Higgins, K.M., Lloyd, R.S. J. Bacteriol. (1986) [Pubmed]
  29. Mutagenicity and co-mutagenicity of static magnetic fields detected by bacterial mutation assay. Ikehata, M., Koana, T., Suzuki, Y., Shimizu, H., Nakagawa, M. Mutat. Res. (1999) [Pubmed]
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