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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Multicenter comparison of cyclacillin and amoxicillin in the treatment of acute streptococcal pharyngitis.

A double-blind study of 134 pediatric outpatients with acute streptococcal pharyngitis demonstrated that cyclacillin, administered three times a day for ten days, is as effective as a similar regimen of amoxicillin. Clinical success was achieved in 95% of the children treated with either drug. A bacteriological cure was seen in 82% of the children evaluated in the cyclacillin group and 90% of those evaluated in the amoxicillin group. The mean time required for remission of signs and symptoms in the respective treatment groups was 3.1 and 3.0 days. Only two patients (3%) in each treatment group experienced an adverse effect of the prescribed drug.[1]


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