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Chemical Compound Review

BSPBio_001840     (2R,5R,6S)-6-[[(2S)-2-amino- 2-(4...

Synonyms: KBioGR_000596, KBioSS_000428, CCG-38922, NINDS_000231, SPBio_000250, ...
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Disease relevance of amoxicillin

  • We conclude that in infants and children with otitis media with effusion, amoxicillin treatment increases to some extent the likelihood of resolution [1].
  • Effect of ranitidine and amoxicillin plus metronidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer [2].
  • To study the effect of the eradication of H. pylori on the recurrence of duodenal ulcer, we treated 104 patients with H. pylori infection and recurrent duodenal ulcer with either amoxicillin (750 mg three times daily) plus metronidazole (500 mg three times daily) or identical-appearing placebos, given orally for 12 days [2].
  • Among both the amoxicillin-treated subjects and the placebo-treated subjects, resolution was more likely in those with initially unilateral effusion, in those who had had effusion for eight weeks or less, and in those without an upper respiratory tract infection at the four-week end point [1].
  • In a randomized, double-blind, placebo-controlled trial involving 518 infants and children who had otitis media with effusion ("secretory" otitis media), we evaluated the efficacy of a two-week course of amoxicillin (40 mg per kilogram of body weight per day) with and without a four-week course of an oral decongestant-antihistamine combination [1].

Psychiatry related information on amoxicillin


High impact information on amoxicillin

  • Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia. Omeprazole plus Clarithromycin and Amoxicillin Effect One Year after Treatment (OCAY) Study Group [7].
  • METHODS: In a multicenter, randomized, double-blind trial, we assessed two treatments for early syphilis: 2.4 million units of penicillin G benzathine and that therapy enhanced with a 10-day course of amoxicillin and probenecid [8].
  • Among the 474 subjects who were evaluated at the four-week end point, the rate of resolution of middle-ear effusion was twice as high in those treated with amoxicillin, either with or without the decongestant-antihistamine, as in those who received placebo (P less than 0.001), but 69.8 percent of the amoxicillin-treated subjects still had effusion [1].
  • Efficacy of single-dose and conventional amoxicillin therapy in urinary-tract infection localized by the antibody-coated bacteria technic [9].
  • Urine specimens from 61 women with symptoms of cystitis who are infected with amoxicillin-sensitive organisms were examined by the antibody-coated bacteria assay [9].

Chemical compound and disease context of amoxicillin


Biological context of amoxicillin


Anatomical context of amoxicillin


Associations of amoxicillin with other chemical compounds


Gene context of amoxicillin


Analytical, diagnostic and therapeutic context of amoxicillin


  1. Efficacy of amoxicillin with and without decongestant-antihistamine for otitis media with effusion in children. Results of a double-blind, randomized trial. Mandel, E.M., Rockette, H.E., Bluestone, C.D., Paradise, J.L., Nozza, R.J. N. Engl. J. Med. (1987) [Pubmed]
  2. Effect of ranitidine and amoxicillin plus metronidazole on the eradication of Helicobacter pylori and the recurrence of duodenal ulcer. Hentschel, E., Brandstätter, G., Dragosics, B., Hirschl, A.M., Nemec, H., Schütze, K., Taufer, M., Wurzer, H. N. Engl. J. Med. (1993) [Pubmed]
  3. A randomized, prospective trial comparing amoxicillin and erythromycin for the treatment of Chlamydia trachomatis in pregnancy. Silverman, N.S., Sullivan, M., Hochman, M., Womack, M., Jungkind, D.L. Am. J. Obstet. Gynecol. (1994) [Pubmed]
  4. Baboon syndrome resulting from systemic drugs: is there strife between SDRIFE and allergic contact dermatitis syndrome? Häusermann, P., Harr, T., Bircher, A.J. Contact Derm. (2004) [Pubmed]
  5. Relation between alcohol consumption and the success of Helicobacter pylori eradication therapy using omeprazole, clarithromycin and amoxicillin for 1 week. Baena, J.M., López, C., Hidalgo, A., Rams, F., Jiménez, S., García, M., Hernández, M.R. European journal of gastroenterology & hepatology. (2002) [Pubmed]
  6. Amoxicillin-induced nephritis and tubulitis in a child. Ferrara, P., D'Aleo, C.M., Rigante, D., Paolini Paoletti, F., Zannoni, G., Venuti, L., Fundarò, C., Rendeli, C., Salvaggio, E. Urologia internationalis. (2003) [Pubmed]
  7. Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia. Omeprazole plus Clarithromycin and Amoxicillin Effect One Year after Treatment (OCAY) Study Group. Blum, A.L., Talley, N.J., O'Moráin, C., van Zanten, S.V., Labenz, J., Stolte, M., Louw, J.A., Stubberöd, A., Theodórs, A., Sundin, M., Bolling-Sternevald, E., Junghard, O. N. Engl. J. Med. (1998) [Pubmed]
  8. A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. The Syphilis and HIV Study Group. Rolfs, R.T., Joesoef, M.R., Hendershot, E.F., Rompalo, A.M., Augenbraun, M.H., Chiu, M., Bolan, G., Johnson, S.C., French, P., Steen, E., Radolf, J.D., Larsen, S. N. Engl. J. Med. (1997) [Pubmed]
  9. Efficacy of single-dose and conventional amoxicillin therapy in urinary-tract infection localized by the antibody-coated bacteria technic. Fang, L.S., Tolkoff-Rubin, N.E., Rubin, R.H. N. Engl. J. Med. (1978) [Pubmed]
  10. The treatment of chancroid. Schmid, G.P. JAMA (1986) [Pubmed]
  11. Single-dose therapy for cystitis in women. A comparison of trimethoprim-sulfamethoxazole, amoxicillin, and cyclacillin. Hooton, T.M., Running, K., Stamm, W.E. JAMA (1985) [Pubmed]
  12. Antibiotic prophylaxis of experimental endocarditis after dental extractions. Malinverni, R., Overholser, C.D., Bille, J., Glauser, M.P. Circulation (1988) [Pubmed]
  13. Lyme disease: a growing threat to urban populations. Steere, A.C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  14. Probing active site chemistry in SHV beta-lactamase variants at Ambler position 244. Understanding unique properties of inhibitor resistance. Thomson, J.M., Distler, A.M., Prati, F., Bonomo, R.A. J. Biol. Chem. (2006) [Pubmed]
  15. Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer. Furuta, T., Ohashi, K., Kamata, T., Takashima, M., Kosuge, K., Kawasaki, T., Hanai, H., Kubota, T., Ishizaki, T., Kaneko, E. Ann. Intern. Med. (1998) [Pubmed]
  16. Amoxicillin pharmacokinetics in pregnant women: modeling and simulations of dosage strategies. Andrew, M.A., Easterling, T.R., Carr, D.B., Shen, D., Buchanan, M.L., Rutherford, T., Bennett, R., Vicini, P., Hebert, M.F. Clin. Pharmacol. Ther. (2007) [Pubmed]
  17. Amoxicillin intestinal absorption reduction by amiloride: possible role of the Na(+) -H+ exchanger. Westphal, J.F., Jehl, F., Brogard, J.M., Carbon, C. Clin. Pharmacol. Ther. (1995) [Pubmed]
  18. Kinetics of intravenous amoxicillin in patients on long-term dialysis. Francke, E.L., Appel, G.B., Neu, H.C. Clin. Pharmacol. Ther. (1979) [Pubmed]
  19. Redirection of allergen-specific TH2 responses by a modified adenine through Toll-like receptor 7 interaction and IL-12/IFN release. Filì, L., Ferri, S., Guarna, F., Sampognaro, S., Manuelli, C., Liotta, F., Cosmi, L., Matucci, A., Vultaggio, A., Annunziato, F., Maggi, E., Guarna, A., Romagnani, S., Parronchi, P. J. Allergy Clin. Immunol. (2006) [Pubmed]
  20. Effect of omeprazole on the distribution of metronidazole, amoxicillin, and clarithromycin in human gastric juice. Goddard, A.F., Jessa, M.J., Barrett, D.A., Shaw, P.N., Idström, J.P., Cederberg, C., Spiller, R.C. Gastroenterology (1996) [Pubmed]
  21. Campylobacter pyloridis-associated chronic active antral gastritis. A prospective study of its prevalence and the effects of antibacterial and antiulcer treatment. Rauws, E.A., Langenberg, W., Houthoff, H.J., Zanen, H.C., Tytgat, G.N. Gastroenterology (1988) [Pubmed]
  22. Prophylaxis for infective endocarditis: an update. Kaye, D. Ann. Intern. Med. (1986) [Pubmed]
  23. Potential involvement of dendritic cells in delayed-type hypersensitivity reactions to beta-lactams. Rodriguez-Pena, R., Lopez, S., Mayorga, C., Antunez, C., Fernandez, T.D., Torres, M.J., Blanca, M. J. Allergy Clin. Immunol. (2006) [Pubmed]
  24. What other regimens are under investigation to treat Helicobacter pylori infection? Unge, P. Gastroenterology (1997) [Pubmed]
  25. Minocycline-induced cell-mediated hypersensitivity pneumonitis. Guillon, J.M., Joly, P., Autran, B., Denis, M., Akoun, G., Debré, P., Mayaud, C. Ann. Intern. Med. (1992) [Pubmed]
  26. Risk of acute liver injury associated with the combination of amoxicillin and clavulanic acid. García Rodríguez, L.A., Stricker, B.H., Zimmerman, H.J. Arch. Intern. Med. (1996) [Pubmed]
  27. Impact of acid secretion, gastritis, and mucus thickness on gastric transfer of antibiotics in rats. Sherwood, P.V., Wibawa, J.I., Atherton, J.C., Jordan, N., Jenkins, D., Barrett, D.A., Shaw, P.N., Spiller, R.C. Gut (2002) [Pubmed]
  28. In utero and in vitro exposure to beta-lactams impair kidney development in the rat. Nathanson, S., Moreau, E., Merlet-Benichou, C., Gilbert, T. J. Am. Soc. Nephrol. (2000) [Pubmed]
  29. Ampicillin-sulbactam and amoxicillin-clavulanate susceptibility testing of Escherichia coli isolates with different beta-lactam resistance phenotypes. Oliver, A., Pérez-Vázquez, M., Martínez-Ferrer, M., Baquero, F., De Rafael, L., Cantón, R. Antimicrob. Agents Chemother. (1999) [Pubmed]
  30. Effect of hyperproduction of TEM-1 beta-lactamase on in vitro susceptibility of Escherichia coli to beta-lactam antibiotics. Wu, P.J., Shannon, K., Phillips, I. Antimicrob. Agents Chemother. (1994) [Pubmed]
  31. In vitro activities of co-amoxiclav at concentrations achieved in human serum against the resistant subpopulation of heteroresistant Staphylococcus aureus: a controlled study with vancomycin. Prieto, J., Aguilar, L., Giménez, M.J., Toro, D., Gómez-Lus, M.L., Dal-Ré, R., Balcabao, I.P. Antimicrob. Agents Chemother. (1998) [Pubmed]
  32. Resolution of Helicobacter pylori-associated gastric lymphoproliferative disease in a child. Blecker, U., McKeithan, T.W., Hart, J., Kirschner, B.S. Gastroenterology (1995) [Pubmed]
  33. Comparative, multicenter studies of cefixime and amoxicillin in the treatment of respiratory tract infections. Kiani, R., Johnson, D., Nelson, B. Am. J. Med. (1988) [Pubmed]
  34. Behaviour of acid secretion, gastrin release, serum pepsinogen I, and gastric emptying of liquids over six months from eradication of helicobacter pylori in duodenal ulcer patients. A controlled study. Parente, F., Maconi, G., Sangaletti, O., Minguzzi, M., Vago, L., Bianchi Porro, G. Gut (1995) [Pubmed]
  35. Comparison of 1 and 2 weeks of omeprazole, amoxicillin and clarithromycin treatment for Helicobacter pylori eradication: the HYPER Study. Zagari, R.M., Bianchi-Porro, G., Fiocca, R., Gasbarrini, G., Roda, E., Bazzoli, F. Gut (2007) [Pubmed]
  36. Differential absorption of amoxicillin from the human small and large intestine. Barr, W.H., Zola, E.M., Candler, E.L., Hwang, S.M., Tendolkar, A.V., Shamburek, R., Parker, B., Hilty, M.D. Clin. Pharmacol. Ther. (1994) [Pubmed]
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