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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Murine myeloid leukemia: in vivo suppression by sericystatin A, a proteinase inhibitor from leukocytes.

Parenteral administration of sericystatin A, an intracellular leukocyte inhibitor of the proinsulin- splitting enzyme cathepsin B, prolongs the mean survival time of mice with insulin-dependent myeloid leukemia. Sericystatin A reduces the supranormal blood levels of substances detectable by insulin-specific radioimmunoassay in these animals; this effect is abolished by concomitant insulin administration. It is concluded that sericystatin A reduces tumor proliferation indirectly, i.e. by reducing circulating insulin levels.[1]

References

  1. Murine myeloid leukemia: in vivo suppression by sericystatin A, a proteinase inhibitor from leukocytes. Pavelić, K., Sirotković, M., Kopitar, M., Pavelić, J., Vuk-Pavlović, S. European journal of cancer & clinical oncology. (1983) [Pubmed]
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